Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (8): 1292-1296.doi: 10.16352/j.issn.1001-6325.2022.08.1292

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Research progress on the effects of mineralocorticoid receptor on cardiovascular diseases

MA Qian-yu1, PENG Shi1, ZHANG Zhao-yuan1, ZHANG Dan1, ZHANG Jin2*   

  1. 1. the First Clinical Medical College of Lanzhou University; 2. Gansu Provincial Key Laboratory of Cardiovascular Disease, Department of Cardiology,the First Hospital of Lanzhou University; Lanzhou 730000,China
  • Received:2021-05-24 Revised:2021-08-06 Online:2022-08-05 Published:2022-08-01
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Abstract: The mineralocorticoid receptor (MR) is a ligand-activated cytoplasmic receptor.Activation of MR in different cells can cause cardiovascular inflammation, oxidative stress, tissue remodeling ,and even function change the activity of ion channels resulting in incidence of arrhythmia through various mechanisms.MR antagonists are effective medicine to treat hypertension,coronary heart disease,and heart failure. In addition, the role of MR in arrhythmia and pulmonary hypertension also provides new perspectives for future clinical medication.

Key words: mineralocorticoid receptor, cardiovascular disease, mechanism

CLC Number: