Research progress on the role of FOXC1 in the development of digestive system cancer

doi:10.16352/j.issn.1001-6325.2024.07.1049

Abstract

Abstract: forkhead box protein C1(FOXC1) is a cancer-related transcription factor that plays an important role in various signaling pathways related to cancer development.FOXC1 is involved in the regulation of cancer cells from many aspects, including proliferation, metastasis and recurrence.FOXC1 can promote cell cycle progression and cell proliferation by up-regulating the expression of oncogenes, such as cyclin D1.FOXC1 promotes epithelial-mesenchymal transition (EMT), in which cells change from polarized epithelial cells to cells with stromal characteristics, which contributes to tumor cell infiltration and migration.FOXC1 may play a role in tumor angiogenesis by regulating genes associated with angiogenesis.FOXCI can enhance cell migration and invasion by regulating reactive oxygen species and activating β-catenin expression.In summary, FOXC1 functions through a variety of mechanisms.

Key words: the FOX family, FOXC1, digestive system cancers, signal pathway

CLC Number:

R735

JIN Qing, DING Youming. Research progress on the role of FOXC1 in the development of digestive system cancer[J]. Basic & Clinical Medicine, 2024, 44(7): 1049-1053.

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