Progress on the role of transketolase in occurrence and treatment of diabetes and its complications

doi:10.16352/j.issn.1001-6325.2024.07.1023

Abstract

Abstract: Transketolase (TKT) is an important enzyme that catalyzes the non-oxidative phase group transfer reaction of pentose phosphate pathway (PPP), and is involved in the metabolism of various energy substances in the body, such as glucose, ribose, nucleotides and lipids. TKT can reduce oxidative stress, inflammation, atherosclerosis, endothelial dysfunction and Tau protein phosphorylation by inhibiting advanced glycated end-produces(AGEs) produced by non-enzymatic glycosylation (NEG) of proteins and lipids in a high-glucose environment improving blood glucose, glucose tolerance and β cell function so to prevent and treat diabetes and its complications. This article reviews research progress on the mechanism of TKT in the treatment of diabetes mellitus and its complications.

Key words: transketolase, diabetes, metabolism, pentose phosphate pathway

CLC Number:

WANG Zeying, LIU Zhi, TAI Yu, YANG Zhongbin, SU Yan. Progress on the role of transketolase in occurrence and treatment of diabetes and its complications[J]. Basic & Clinical Medicine, 2024, 44(7): 1023-1028.

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