Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism

doi:10.16352/j.issn.1001-6325.2024.01.0119

Abstract

Abstract: A close relationship between fatty acid metabolism and cancer development is well-established. The hydroxyacyl-coenzyme a dehydrogenase (HADH), a key enzyme in fatty acid beta-oxidation, has recently been identified as an anti-oncogenic factor in various cancers and an oncogenic factor in conditions like acute myeloid leukemia. In cancer cells, HADH not only directly catalyzes fatty acid beta-oxidation but also indirectly influences multiple signaling pathways such as PPAR, TNF-α, JAK-STAT3, PI3K/Akt, IFN-γ, MAPK, and non-canonical Wnt signaling pathways, affecting cancer cell proliferation and migration. HADH shows promise as a potential tumor biomarker for diagnosis, treatment, and prognosis in different cancer types, holding significant clinical value.

Key words: hydroxyacyl-coenzyme A dehydrogenase, lipid metabolism, fatty acid β-oxidation, tumor suppressor gene, tumor marker

CLC Number:

WU Guojia, ZHAI Shujie, SUN Xiao, HUANG Yiran, LI Yongmei, SUN Li. Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism[J]. Basic & Clinical Medicine, 2024, 44(1): 119-123.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2024.01.0119

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2024/V44/I1/119

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