基础医学与临床 ›› 2022, Vol. 42 ›› Issue (3): 372-377.doi: 10.16352/j.issn.1001-6325.2022.03.033

• 特邀专题:聚焦动脉粥样硬化斑块稳定性 • 上一篇    下一篇

血管老化在动脉粥样硬化中的研究进展

张琦悦, 张伟丽*   

  1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心血管疾病国家重点实验室,北京 100037
  • 收稿日期:2021-12-30 修回日期:2022-01-20 出版日期:2022-03-05 发布日期:2022-03-04
  • 通讯作者: * zhang-weili1747@yahoo.com
  • 基金资助:
    国家自然科学基金面上项目(82070373)

The role of vascular aging in atherosclerosis

ZHANG Qi-yue, ZHANG Wei-li*   

  1. State Key Laboratory of Cardiovascular Diseases, National Center for Cardiovascular Diseases and Fuwai Hospital, CAMS & PUMC, Beijing 100037, China
  • Received:2021-12-30 Revised:2022-01-20 Online:2022-03-05 Published:2022-03-04
  • Contact: * zhang-weili1747@yahoo.com

摘要: 血管老化是血管的结构和功能随年龄增长呈现年龄依赖性的退行性改变,可导致心血管疾病的患病风险显著增加。动脉粥样硬化是多种心血管疾病的病理生理基础,血管老化在动脉粥样硬化的发生发展中发挥重要作用。有效评估血管老化对动脉粥样硬化性心血管疾病的临床诊疗意义重大。本文总结了血管老化的结构和功能性变化,阐述血管老化过程中血管细胞端粒磨损、线粒体功能障碍和炎性反应在动脉粥样硬化中的重要作用,以期为动脉粥样硬化疾病的预防和诊治提供新思路。

关键词: 血管老化, 动脉粥样硬化, 端粒磨损, 线粒体功能障碍, 炎性反应

Abstract: Vascular aging is an age-dependent degeneration of vascular structure and function, which can lead to an increased risk of cardiovascular diseases. Atherosclerosis is an essential pathogenesis of cardiovascular diseases. Vascular aging plays an important role in the progression of atherosclerosis. Effective evaluation of vascular aging is necessary for the clinical treatment of atherosclerotic diseases. This review summarized the structural and functional changes of vascular aging, and highlighted the important roles of telomere attrition, mitochondrial dysfunction and inflammation of vascular cells in the process of atherosclerosis, aiming to provide new impetus for the clinical treatment of atherosclerotic diseases.

Key words: vascular aging, atherosclerosis, telomere attrition, mitochondrial dysfunction, inflammation

中图分类号: