基础医学与临床 ›› 2021, Vol. 41 ›› Issue (3): 428-432.

• 短篇综述 • 上一篇    下一篇

代谢相关生物学标记物在老年人衰弱中的研究进展

潘一鸣,李耘,马丽娜   

  1. 首都医科大学宣武医院
  • 收稿日期:2020-05-06 修回日期:2020-06-25 出版日期:2021-03-05 发布日期:2021-03-01
  • 通讯作者: 马丽娜 E-mail:malina0883@126.com
  • 基金资助:
    国家重点研发计划;北京市自然科学基金;北京市属医院科研培育项目;米尔斯坦亚美医学基金会老年健康专项

Research progress on metabolism-related biomarkers of frailty in the elderly

  • Received:2020-05-06 Revised:2020-06-25 Online:2021-03-05 Published:2021-03-01

摘要: 衰弱是伴有数个器官系统生理机能下降的老年综合征,会导致跌倒、认知障碍、住院和死亡等不良后果。早期诊断衰弱对于促进健康老龄化具有重要价值。衰弱的诊断目前依赖于各种评估工具,缺乏特异性的生物学标志物。衰弱常伴随能量、肌肉、骨骼、激素等多方面的代谢紊乱,故代谢相关生物标志物的研究可为衰弱的早期识别和干预提供新思路。

关键词: 衰弱, 代谢, 生物学标记物, 诊断, 老年人

Abstract: Frailty is a common syndrome in the elderly, identified by the decline of physiological functions in multiple organ systems, which may lead to adverse outcomes such as falls, cognitive impairment, hospitalization or death. Early diagnosis of frailty is of great value in promoting healthy aging. At present, it can only be diagnosed by assessment tools in clinical without specific biomarkers. Frailty is often accompanied by metabolic disorders in many aspects, such as energy, muscle, bone, hormone and so on. The study of metabolism-related biomarkers can help early identification and intervention of frailty.

Key words: frailty, metabolism, biomarkers, diagnose, elderly