心外膜在心肌梗死后心肌修复中作用的研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (10): 1421-1425.

心外膜在心肌梗死后心肌修复中作用的研究进展

孙洋¹, 张岩^2*

1.中国医学科学院北京协和医学院阜外医院国家心血管病中心病理科;
2.中国医学科学院北京协和医学院阜外医院国家心血管病中心心外科, 北京 100037

收稿日期:2019-04-08 修回日期:2019-10-12 出版日期:2020-10-05 发布日期:2020-09-29
通讯作者: ^* waikezhangyan@126.com
基金资助:
北京市自然科学基金(7162161)

Progress of the role of epicardium in myocardial repair after myocardial infarction

SUN Yang¹, ZHANG Yan^2*

1. Department of Pathology;
2. Department of Cardiac Surgery, National Center for Cardiovascular Disease,Fuwai Hospital, CAMS ＆ PUMC,Beijing 100037, China

Received:2019-04-08 Revised:2019-10-12 Online:2020-10-05 Published:2020-09-29
Contact: ^* waikezhangyan@126.com

摘要/Abstract

摘要： 心外膜具有高度再生能力和多向分化潜能,能分泌多种信号分子,为心肌再生和组织重塑提供细胞基础和调节信号,是心肌再生领域的研究热点。本文主要阐述激活成人心外膜、调控心外膜分化和制作心外膜生物工程补片。以期基于心外膜的治疗早日应用于临床。

关键词: 心外膜, 心脏, 修复, 再生

Abstract: The epicardium characterized by high regeneration ability and multidirectional differentiation potential, which can secrete a variety of signal molecules, and play a central role during myocardial infarction repair. Current research approaches aims to activate the adult epicardium, to regulate epicardial differentiation, and to make bioengineered epicardial patch to promote heart regeneration. In this Review, we describe recent advances in the biology of the epicardium and attempts using the epicardium as therapeutic targets for heart repair and regeneration.

Key words: epicardium, heart, repairment, regeneration

中图分类号:

R364

孙洋, 张岩. 心外膜在心肌梗死后心肌修复中作用的研究进展[J]. 基础医学与临床, 2020, 40(10): 1421-1425.

SUN Yang, ZHANG Yan. Progress of the role of epicardium in myocardial repair after myocardial infarction[J]. Basic & Clinical Medicine, 2020, 40(10): 1421-1425.

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