关键词: S100A6, 子宫内膜异位症, 增殖, 迁移, 凋亡

Abstract: Objective: To investigate the influence of over-expressed S100A6 on proliferation，migration and apoptosis in eutopic endometrial stromal cells. Methods: The eutopic endometrial stromal cells were cultivated in vitro and divided into Lv-S100A6 group and negative group, which infected with the recombinant lentivirus S100A6 (Lv-S100A6) and recombinant lentivirus vector respectively. CCK-8 assay was performed to identify the proliferation of cell. The cell migration was detected by Transwell chamber. Flow cytometry method was performed to detect cell apoptosis. Results: As compared with the blank group and negative control group, the proliferation was increased in eutopic endometrial stromal cells after transfection with Lv-S100A6 (P＜0.05), the ability of migration was promoted. However, the apoptosis rate in eutopic endometrial stromal cells after transfection with Lv-S100A6（2.99%）was decreased compared with the blank control group（13.48%） and the negative group（14.40%）(P＜0.05). Conclusions: S100A6 can effectively increase the proliferation and migration in eutopic endometrial stromal cells, and inhibit the cell apoptosis.

Key words: S100A6, endometriosis, proliferation, migration, apoptosis