基础医学与临床 ›› 2013, Vol. 33 ›› Issue (10): 1332-1336.
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张体栋,尹艳玲,李俊发
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摘要： 脑衰反应调节蛋白2（CRMP2）在神经元发育过程中发挥着重要作用。CRMP2具有多种翻译后修饰方式和生物学功能，其中磷酸化修饰与神经系统疾病最相关，但其具体机制及生物学作用尚不清楚，有待进一步研究。CRMP2 的研究为防治相关神经系统疾病提供了新的方向。
关键词: 脑衰反应调节蛋白2(CRMP2), 磷酸化, 阿尔茨海默病(AD), 缺血低氧损伤, 精神类疾病
Abstract: Collapsin response mediator protein 2(CRMP2) plays a crucial role in neuronal development. It owns lots of post-translational modifications, of which phosphorylation modification is related to diseases closely. CRMP2 also has many biological functions. There is a close relationship between CRMP2 and neurologic disorders, but the mechanism is required to be elucidated. The researches in CRMP2 provided new strategies to prevent and cure the related diseases.
Key words: CRMP2, Phosphorylation, Alzheimer's Disease, Hypoxia-Ischemia Injury, Psychosis
中图分类号:
R338.1+1
张体栋 尹艳玲 李俊发. 脑衰反应调节蛋白2及其与神经系统疾病关系的研究进展[J]. 基础医学与临床, 2013, 33(10): 1332-1336.
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