孕期锌缺乏及对妊娠结局的影响

doi:10.16352/j.issn.1001-6325.2024.04.0422

摘要/Abstract

摘要： 孕期锌缺乏率较高,迄今研究发现其与自发性早产、复发性流产、低出生体重、小胎龄儿、子痫前期和妊娠期糖尿病等不良妊娠结局存在显著关联。然而,目前缺乏一种特异、灵敏、便于采集和检测的生物标志物用于临床评价锌的营养状况,所幸最新研究发现金属硫蛋白和油酸与二羟甲基γ-亚麻酸的比值(LA/DGLA)具有潜在应用价值。本文重点对孕期锌缺乏与不良妊娠结局、潜在锌生物标志物及锌缺乏治疗的国内外研究进展进行总结与探讨,以期为围产期营养指导提供思路。

关键词: 锌缺乏, 锌生物标志物, 妊娠结局

Abstract: Zinc deficiency during pregnancy is common and has been significantly associated with adverse pregnancy outcomes such as spontaneous preterm birth(PTB), recurrent abortion(RA), low birth weight(LBW), small-for-gestational-age infant(SGA), preeclampsia(PE), and gestational diabetes mellitus(GDM). Unfortunately, there is no specific biomarkers which are sensitive, easy-to-collect and detect available for the clinical evaluation of zinc nutritional status. However, recent studies have identified metallothionein and the ratio of oleic acid to dihydroxymethyl gamma-linolenic acid(LA/DGLA) as potentially candidates of biomarkers.This article focuses on summarizing and discussing the progress of domestic and international researches on zinc deficiency during pregnancy and adverse pregnancy outcomes, potential zinc biomarkers, and zinc deficiency treatments, aiming at providing ideas for perinatal nutritional guidance.

Key words: zinc deficiency, zinc biomarkers, pregnancy outcome

中图分类号:

R153.1

李运龙, 李蕊, 张玉萍, 王瑞, 刘燕萍. 孕期锌缺乏及对妊娠结局的影响[J]. 基础医学与临床, 2024, 44(4): 422-427.

LI Yunlong, LI Rui, ZHANG Yuping, WANG Rui, LIU Yanping. Zinc deficiency during pregnancy and its effect on pregnancy outcome[J]. Basic & Clinical Medicine, 2024, 44(4): 422-427.

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