新型冠状病毒疫苗接种对妊娠结局的影响

doi:10.16352/j.issn.1001-6325.2023.05.0794

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (5): 794-797.doi: 10.16352/j.issn.1001-6325.2023.05.0794

新型冠状病毒疫苗接种对妊娠结局的影响

张纬¹, 余益香², 王琳², 闻明^2*

芜湖市第一人民医院 1.药剂科; 2.产科,安徽芜湖 241001

收稿日期:2023-02-13 修回日期:2023-03-21 出版日期:2023-05-05 发布日期:2023-04-26
通讯作者: ^*2579243169@qq.com
基金资助:
2022年安徽省重点研究与开发计划科技惠民专项(2022e07020089)

Impact of SARS-CoV-2 vaccination on pregnancy outcome

ZHANG Wei¹, YU Yixiang², WANG Lin², WEN Ming^2*

1. Department of Pharmacy; 2. Department of Obstetrics, the First People's Hospital of Wuhu, Wuhu 241001, China

Received:2023-02-13 Revised:2023-03-21 Online:2023-05-05 Published:2023-04-26
Contact: ^*2579243169@qq.com

摘要/Abstract

摘要： 目的探究新型冠状病毒(SARS-CoV-2)疫苗接种对育龄期妇女妊娠结局的影响。方法纳入2021年5月至2022年11月于多家医联体医院,包括:芜湖市第一人民医院、无为市人民医院、南陵县医院、湾沚区总医院、芜湖市繁昌区人民医院、芜湖海螺医院进行分娩或流产、早产的孕产妇1 987例,其中接种新型冠状病毒疫苗的1 346例,未接种疫苗的641例,并对分娩状况及新生儿出生结局进行记录,包括流产、死产、早产、活产等,和新生儿5分钟Apgar评分、转往新生儿重症监护病房(NICU)等情况。结果接种新型冠状病毒疫苗组与未接种疫苗组孕产妇在妊娠年龄分布、是否为经产妇上均有差异(P＜0.05,P＜0.001);接种疫苗组产妇的胎儿活产率(95.32%)和未接种疫苗组产妇的胎儿活产率(94.70%)差异无统计学意义;排除妊娠结局流产与死产后,两组的分娩结局(包括新生儿形态、质量、NICU以及5分钟Apgar评分)差异无统计学意义。结论与未接种疫苗组育龄期女性相比,接种新型冠状病毒疫苗对于育龄期妇女妊娠结局无影响。

关键词: 新型冠状病毒肺炎, 新型冠状病毒疫苗, 孕产妇, 妊娠结局

Abstract: Objective To explore the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on pregnancy outcome in women of childbearing age. Methods The project was a multi-center investigation covering May 2021 to November 2022 the First People's Hospital of Wuhu, Wuwei City People's Hospital, Nanling Hospital, Wuhu Fanchang District People's Hospital childbirth and abortion. The investigation included 1 987 cases of pregnant and parturient women of childbearing age, with 1 346 cases of SARS-CoV-2 vaccinated, and 641 unvaccinated. Pregnancy outcomes including neonatal weight, 5-minute Apgar score, and neonatal intensive care unit (NICU). Results There were differences between the vaccinated group and the unvaccinated group in age distribution of pregnancy and whether the women were multiparous(P＜0.05,P＜0.001). There was no difference in the fetal live birth rate between the two groups. Excluding pregnancy outcomes abortion and stillbirth, the results showed that there was no differencein delivery outcomes (including neonatal morphology, body weight, NICU and 5-minute Apgar score between the two groups. Conclusions SARS-CoV-2 accination has no negative impact on pregnancy outcome in childbearing women.

Key words: COVID-19, SARS-CoV-2 vaccine, pregnant woman, pregnancy outcome

中图分类号:

R715

张纬, 余益香, 王琳, 闻明. 新型冠状病毒疫苗接种对妊娠结局的影响[J]. 基础医学与临床, 2023, 43(5): 794-797.

ZHANG Wei, YU Yixiang, WANG Lin, WEN Ming. Impact of SARS-CoV-2 vaccination on pregnancy outcome[J]. Basic & Clinical Medicine, 2023, 43(5): 794-797.

参考文献

[1]Nikolich-Zugich J, Knox KS, Rios CT, et al. SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes[J]. Geroscience, 2020, 42: 505-514.
[2]Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020, 382: 727-733.
[3]Goes LR, Siqueira JD, Garrido MM, et al. New infections by SARS-CoV-2 variants of concern after natural infections and post-vaccination in Rio de Janeiro, Brazil[J]. Infect Genet Evol, 2021, 94: 104998. doi: 10.1016/j.meegid.2021.104998.
[4]Zambrano LD, Ellington S, Strid P, et al. Update: Characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States, January 22-October 3, 2020[J]. MMWR Morb Mortal Wkly Rep, 2020, 69: 1641-1647.
[5]Rasmussen SA, Kelley CF, Horton JP, et al. Coronavirus disease 2019 (COVID-19) vaccines and pregnancy: what obstetricians need to know[J]. Obstet Gynecol, 2021, 137: 408-414.
[6]Tekbali A, Grunebaum A, Saraya A, et al. Pregnant vs nonpregnant severe acute respiratory syndrome coronavirus 2 and coronavirus disease 2019 hospital admissions: the first 4 weeks in New York[J]. Am J Obstet Gynecol, 2020, 223: 126-127.
[7]Westgren M, Acharya G. Intensive care unit admissions for pregnant and nonpregnant women with coronavirus disease 2019[J]. Am J Obstet Gynecol, 2020, 223: 779-780.
[8]张露,江燕,魏敏,等.湖北地区新型冠状病毒肺炎流行期间孕妇的妊娠结局分析[J].中华妇产科杂志,2020,55: 166-171.
[9]Ellington S, Strid P, Tong VT, et al. (2020) Characteristics of women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status-United States, January 22-June 7, 2020[J]. MMWR Morb Mortal Wkly Rep, 2020, 69: 769-775.
[10]Khalil A, Kalafat E, Benlioglu C, et al. SARS-CoV-2 infection in pregnancy: a systematic review and meta-analysis of clinical features and pregnancy outcomes[J]. EClinicalMedicine, 2020, 25: 100446. doi: 10.1016/j.eclinm.2020.100446.
[11]Magee LA, Khalil A, von Dadelszen P. Covid-19: UK Obstetric Surveillance System (UKOSS) study in context[J]. BMJ, 2020, 370: m2915. doi: 10.1136/bmj.m2915.
[12]Patel MK, Bergeri I, Bresee JS, et al. (2021) Evaluation of post-introduction COVID-19 vaccine effectiveness: summary of interim guidance of the World Health Organization[J]. Vaccine, 2021, 39: 4013-4024.

[1]	戴玉慧, 陈永辉, 景红丽, 霍力. COVID-19疫情下核医学临床教学的困境与调整[J]. 基础医学与临床, 2022, 42(6): 1007-1009.
[2]	王战勇, 徐静, 梁燕, 岳育红. 孕中期血清唐氏综合征筛查与不良妊娠结局关联[J]. 基础医学与临床, 2022, 42(6): 955-959.
[3]	赵善可, 傅瑶, 褚大鹏, 付磊, 韩烁, 白雪燕, 李媛, 周雯慧. 促性腺激素释放激素拮抗剂方案比激动剂长方案获得更多可利用胚胎[J]. 基础医学与临床, 2022, 42(3): 479-483.
[4]	赵明喆, 魏镜, 段艳平, 赵月, 马良坤. 有主观抑郁症状的孕产妇精神障碍的发生率[J]. 基础医学与临床, 2022, 42(2): 301-305.
[5]	陈宇舟, 戴靖榕, 李茜, 梁雅婷, 吴松林. 张家界市普通型/重型德尔塔新型冠状病毒肺炎与血清白蛋白相关性分析[J]. 基础医学与临床, 2022, 42(11): 1751-1754.
[6]	李雨婷, 范永君, 孟琰, 隋芳, 韩常新. 辽南地区2020年度COVID-19流行病学及临床特征分析[J]. 基础医学与临床, 2022, 42(10): 1577-1580.
[7]	刘旭之, 武立刚, 张世阳, 赵炜明, 王斌, 王皓晴. 纤连蛋白(FN)雾化吸入治疗COVID-19的临床效果观察[J]. 基础医学与临床, 2021, 41(8): 1174-1176.
[8]	杨诗婕, 徐协群. 新型冠状病毒肺炎疫情下医学生的参与及其启示[J]. 基础医学与临床, 2021, 41(8): 1234-1237.
[9]	马明圣, 张天楠, 贾雪妍, 罗林枝. COVID-19疫情期间临床研究生焦虑、抑郁情况调查及相关因素分析[J]. 基础医学与临床, 2021, 41(7): 1084-1086.
[10]	于志君, 卢莉莉, 王育斌, 江珍玉, 邓海英. COVID-19疫情背景下医学微生物学线上实验教学实践探索[J]. 基础医学与临床, 2021, 41(4): 602-606.
[11]	陈云坤, 刘煌, 张文斌, 王杰. 52例COVID-19患者出院后核酸复检阳性的中医证型分析[J]. 基础医学与临床, 2021, 41(4): 558-561.
[12]	焦洋, 李玥, 李航, 张奉春. 新型冠状病毒肺炎后疫情时期内科住院医师培养的思考[J]. 基础医学与临床, 2021, 41(10): 1546-1549.
[13]	孟伟, 王若蛟, 吕珂, 张一休, 李建初, 李文波, 王铭. COVID-19疫情期间非隔离诊区超声设备的消毒[J]. 基础医学与临床, 2020, 40(9): 1261-1265.
[14]	王淼蕾, 刘俊宏, 汪龙德, 毛兰芳, 张萍, 符博雅. 中西医诊治新型冠状病毒肺炎[J]. 基础医学与临床, 2020, 40(7): 893-896.
[15]	陈婷婷, 石坤, 杨艳峰, 柳颐龄, 李焰, 郭永宏, 王献民. 新型冠状病毒肺炎疫情期间儿科住院医师规范化培训教学探索[J]. 基础医学与临床, 2020, 40(6): 750-752.

新型冠状病毒疫苗接种对妊娠结局的影响

Impact of SARS-CoV-2 vaccination on pregnancy outcome

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价