脂蛋白相关磷脂酶A2在急性冠状动脉综合征中作用的研究进展

doi:10.16352/j.issn.1001-6325.2024.01.0103

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (1): 103-107.doi: 10.16352/j.issn.1001-6325.2024.01.0103

脂蛋白相关磷脂酶A2在急性冠状动脉综合征中作用的研究进展

郭健宏, 王亚玲^*, 崔文光

河北北方学院附属第一医院心血管内科,河北张家口 075000

收稿日期:2023-04-07 修回日期:2023-09-26 出版日期:2024-01-05 发布日期:2023-12-25
通讯作者: ^*:1907577068@qq.com
基金资助:
张家口市科学技术研究与发展计划(1911021D-1)

Research progress on the role of lipoprotein- associated phospholipase A2 in acute coronary syndrome

GUO Jianhong, WANG Yaling^*, CUI Wenguang

Department of Cardiovascular Medicine, the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000,China

Received:2023-04-07 Revised:2023-09-26 Online:2024-01-05 Published:2023-12-25
Contact: ^*:1907577068@qq.com

摘要/Abstract

摘要： 脂蛋白相关磷脂酶A2(Lp-PLA2)是一种由441个氨基酸组成的蛋白。Lp-PLA2能够促进炎细胞向炎性反应部位聚集及炎性因子的释放,促进基质金属蛋白酶的合成,使动脉粥样硬化斑块内泡沫细胞及细胞外基质增多,并且使斑块纤维帽变薄而易于破裂,进而促进急性冠脉综合征(ACS)的发病。因此在急性冠脉综合征患者中测定和调节Lp-PLA2水平具有重要的临床意义。

关键词: 脂蛋白相关磷脂酶A2, 急性冠脉综合征, 动脉粥样硬化

Abstract: Lipoprotein-associated phospholipase A2(Lp-PLA2) is a protein composed of 441 amino acids, which can promote the aggregation of inflammatory cells to the inflammatory response site and the release of inflammatory factors. It can promote the synthesis of matrix metalloproteinases, increase the number of foam cells and extra cellular matrix in atherosclerotic plaque, attenuate plaque fiber cap and prone to rupture, thus promote the onset of acute coronary syndrome(ACS). Therefore, the determination and regulation of Lp-PLA2 levels in patients with ACS are clinically significant.

Key words: lipoprotein-associated phospholipase A2, acute coronary syndrome, atherosclerosis

中图分类号:

R541.4

郭健宏, 王亚玲, 崔文光. 脂蛋白相关磷脂酶A2在急性冠状动脉综合征中作用的研究进展[J]. 基础医学与临床, 2024, 44(1): 103-107.

GUO Jianhong, WANG Yaling, CUI Wenguang. Research progress on the role of lipoprotein- associated phospholipase A2 in acute coronary syndrome[J]. Basic & Clinical Medicine, 2024, 44(1): 103-107.

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脂蛋白相关磷脂酶A2在急性冠状动脉综合征中作用的研究进展

Research progress on the role of lipoprotein- associated phospholipase A2 in acute coronary syndrome

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