氧化应激增加多囊卵巢综合征患者心血管疾病风险的研究进展

doi:10.16352/j.issn.1001-6325.2022.12.1950

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (12): 1950-1954.doi: 10.16352/j.issn.1001-6325.2022.12.1950

氧化应激增加多囊卵巢综合征患者心血管疾病风险的研究进展

李欢欢^1,2, 张玉齐^1,2, 吕海宏^2*

1.兰州大学第一临床医学院,甘肃兰州 730000;
2.兰州大学第一医院内分泌科, 甘肃兰州 730000

收稿日期:2021-07-28 修回日期:2021-12-08 出版日期:2022-12-05 发布日期:2022-11-23
通讯作者: ^* haihonglv@126.com
基金资助:
兰州市城关区科技计划(2021JSCX0011)

Research progress of oxidative stress increasing the risk of cardiovascular disease of polycystic ovary syndrome patients

LI Huan-huan^1,2, ZHANG Yu-qi^1,2, LYU Hai-hong^2*

1. the First Clinical Medical School, Lanzhou University, Lanzhou 730000;
2. Department of Endocrinology,the First Hospital of Lanzhou University,Lanzhou 730000,China

Received:2021-07-28 Revised:2021-12-08 Online:2022-12-05 Published:2022-11-23
Contact: ^* haihonglv@126.com

摘要/Abstract

摘要： 多囊卵巢综合征(PCOS)与肥胖、高胰岛素血症、糖耐量受损、高雄激素血症、慢性炎性反应、血脂异常和高血压等相关,关键与氧化应激(OS)有关,后者是导致心血管疾病(CVD)风险因素之一。本文综述了多囊卵巢综合征中氧化应激增加CVD风险的机制及阻断活性氧(ROS)产生路径防治PCOS患者心血管疾病发生的可能性。

关键词: 多囊卵巢综合征, 氧化应激, 内皮功能障碍, 动脉粥样硬化

Abstract: Polycystic ovary syndrome (PCOS) is related to obesity, hyperinsulinemia, impaired glucose toler-ance, hyperandrogenism, chronic inflammatory response, dyslipidemia and hypertension. PCOS is critically associated with oxidative stress (OS), which is a risk factor for cardiovascular disease (CVD). This article reviews the mechanisms by which OS increases the risk of CVD in PCOS and the possibility of preventing CVD in PCOS patients by blocking the pathway of reactive oxygen species (ROS) production.

Key words: polycystic ovary syndrome, oxidative stress, endothelial dysfunction, atherosclerosis

中图分类号:

R588.6

李欢欢, 张玉齐, 吕海宏. 氧化应激增加多囊卵巢综合征患者心血管疾病风险的研究进展[J]. 基础医学与临床, 2022, 42(12): 1950-1954.

LI Huan-huan, ZHANG Yu-qi, LYU Hai-hong. Research progress of oxidative stress increasing the risk of cardiovascular disease of polycystic ovary syndrome patients[J]. Basic & Clinical Medicine, 2022, 42(12): 1950-1954.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/10.16352/j.issn.1001-6325.2022.12.1950

http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2022/V42/I12/1950

参考文献

[1]Skrzynska KJ, Zachurzok A, Gawlik AM. Metabolic and hormonal profile of adolescent girls with polycystic ovary syndrome with concomitant autoimmune thyroiditis[J]. Front Endocrinol, 2021, 12: 708910. doi: 10.3389/fendo.2021.708910.
[2]Joksimovic Jovic J, Sretenovic J, Jovic N, et al. Cardiovascular properties of the androgen-induced PCOS model in rats: the role of oxidative stress[J]. Oxid Med Cell Longev, 2021, 2021: 8862878. doi: 10.1155/2021/8862878.
[3]刘刚, 郭山岭, 胡永寸,等. 沉默VCAM-1基因降低ox-LDL诱导的HUVECs氧化损伤和凋亡[J].基础医学与临床,2019, 39: 1423-1426.
[4]Shukla P, Mukherjee S. Mitochondrial dysfunction: an emerging link in the pathophysiology of polycystic ovary syndrome[J]. Mitochondrion, 2020, 52: 24-39.
[5]Ansari MY, Ahmad N, Haqqi TM. Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols[J]. Biomed Pharmacother, 2020, 129: 110452. doi: 10.1016/j.biopha.2020.110452.
[6]Gong Y, Luo S, Fan P, et al. Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial[J]. Sci Rep, 2020, 10: 18769. doi: 10.1038/s41598-020-75107-4.
[7]Garcia-Sanchez A, Miranda-Diaz AG, Cardona-Munoz EG. The role of oxidative stress in physiopathology and pharmacological treatment with pro-and antioxidant properties in chronic diseases[J]. Oxid Med Cell Longev, 2020, 2020: 2082145. doi: 10.1155/2020/2082145.
[8]Bannigida DM, Nayak BS, Vijayaraghavan R. Insulin resistance and oxidative marker in women with PCOS[J]. Arch Physiol Biochem, 2020, 126: 183-186.
[9]Jamilian M, Mansury S, Bahmani F, et al. The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome[J]. J Ovarian Res, 2018, 11: 80. doi: 10.1186/s13048-018-0457-1.
[10]Artimani T, Karimi J, Mehdizadeh M, et al. Evaluation of pro-oxidant-antioxidant balance (PAB) and its association with inflammatory cytokines in polycystic ovary syndrome (PCOS)[J]. Gynecol Endocrinol, 2018, 34: 148-152.
[11]Mizgier M, Jarzabek-Bielecka G, Wendland N, et al. Relation between inflammation, oxidative stress, and macronutrient intakes in normal and excessive body weight adolescent girls with clinical features of polycystic ovary syndrome[J]. Nutrients, 2021, 13:896. doi: 10.3390/nu13030896.
[12]Karamali M, Eghbalpour S, Rajabi S, et al. Effects of probiotic supplementation on hormonal profiles, biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial[J]. Arch Iran Med, 2018, 21: 1-7.
[13]Liu Y, Liu H, Li Z, et al. The release of peripheral immune inflammatory cytokines promote an inflammatory cascade in PCOS patients via altering the follicular microenvironment[J]. Front Immunol, 2021, 12: 685724. doi: 10.3389/fimmu.2021.685724.
[14]Liu Q, Xie YJ, Qu LH, et al. Dyslipidemia involvement in the development of polycystic ovary syndrome[J]. Taiwan J Obstet Gynecol, 2019, 58: 447-453.
[15]Nakayama A, Morita H, Kawahara T, et al. Association between testosterone and lipid profiles under statin therapy and its clinical impact on the cardiovascular event risk[J]. Heart Vessels, 2021. 36:1794-1803.
[16]Gonzalez F, Considine RV, Abdelhadi OA, et al. Oxidative stress in response to saturated fat ingestion is linked to insulin resistance and hyperandrogenism in polycystic ovary syndrome[J]. J Clin Endocrinol Metab, 2019, 104: 5360-5371.
[17]Wang D, Wang T, Wang R, et al. Suppression of p66Shc prevents hyperandrogenism-induced ovarian oxidative stress and fibrosis[J]. J Transl Med, 2020, 18: 84. doi: 10.1186/s12967-020-02249-4.
[18]Forstermann U. Nitric oxide and oxidative stress in vascular disease[J]. Pflugers Arch, 2010, 459: 923-939.
[19]Adoga JO, Channa ML, Nadar A. Kolaviron attenuates cardiovascular injury in fructose-streptozotocin induced type-2 diabetic male rats by reducing oxidative stress, inflammation, and improving cardiovascular risk markers[J]. Biomed Pharmacother, 2021, 144: 112323. doi: 10.1016/j.biopha.2021.112323.
[20]Liao Y, Zhu E, Zhou W. Ox-LDL aggravates the oxidative stress and inflammatory responses of THP-1 macrophages by reducing the inhibition effect of miR-491-5p on MMP-9[J]. Front Cardiovasc Med, 2021, 8: 697236. doi: 10.3389/fcvm.2021.697236.
[21]Geng H, Wang A, Rong G, et al. The effects of ox-LDL in human atherosclerosis may be mediated in part via the toll-like receptor 4 pathway[J]. Mol Cell Biochem, 2010, 342: 201-206.
[22]王美惠, 毕徐堃, 傅国胜. 瑞舒伐他汀减轻脂多糖诱导的人晚期内皮祖细胞损伤[J].基础医学与临床,2019, 39: 769-775.
[23]Wassmann S, Laufs U, Baumer AT, et al. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species[J]. Hypertension, 2001, 37: 1450-1457.
[24]Izadi A, Ebrahimi S, Shirazi S, et al. Hormonal and metabolic effects of coenzyme Q10 and/or vitamin E in patients with polycystic ovary syndrome[J]. J Clin Endocrinol Metab, 2019, 104: 319-327.
[25]Rahmani E, Samimi M, Ebrahimi FA, et al. The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome[J]. Mol Cell Endocrinol, 2017, 439: 247-255.

氧化应激增加多囊卵巢综合征患者心血管疾病风险的研究进展

Research progress of oxidative stress increasing the risk of cardiovascular disease of polycystic ovary syndrome patients

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	朱冰, 王旭. 斑点追踪成像技术在缺血性心脏病诊断中的应用[J]. 基础医学与临床, 2022, 42(9): 1459-1463.
[2]	刘珍竹, 李靖, 何丹, 曲鹏. PI3K信号通路调控动脉粥样硬化发生发展的研究进展[J]. 基础医学与临床, 2022, 42(9): 1428-1432.
[3]	赵茂宇, 李佑美, 刘焕云, 毛琦. 胰岛素抵抗标志物在动脉粥样硬化发病中的研究进展[J]. 基础医学与临床, 2022, 42(8): 1302-1305.
[4]	余子强, 徐久平, 詹长生, 邵明峰, 邹建安. 输尿管软镜碎石与经皮肾镜碎石对3 cm以下肾结石疗效和炎性反应的影响[J]. 基础医学与临床, 2022, 42(8): 1259-1262.
[5]	谢思安, 徐俊玄, 宁婷婷, 张楠, 朱圣韬, 刘思. VAV1是动脉粥样硬化预后的潜在靶点和生物标志物[J]. 基础医学与临床, 2022, 42(7): 1092-1098.
[6]	郭婧, 李亚洁, 牟寒霜. LncRNA FGD5-AS1靶向miR-106a-5p减轻ox-LDL诱导的HUVECs损伤[J]. 基础医学与临床, 2022, 42(5): 768-775.
[7]	鲍敏, 林玫, 甄海宁, 何芳, 丁敏, 袁竹青, 陈亚隽, 薛欣欣. 醛糖还原酶抑制剂抑制屋尘螨诱导的人支气管上皮细胞系BEAS-2氧化应激反应[J]. 基础医学与临床, 2022, 42(4): 616-621.
[8]	李杰, 浦洋, 张梦迪, 张鹏举, 许寅喆. mTOR活化上调MGST1并增强细胞抗氧化能力[J]. 基础医学与临床, 2022, 42(4): 553-559.
[9]	裘耀扬, 桂家辉, 黄林, 虎学强, 李勤. 血管内光学相干层析成像技术在冠状动脉粥样硬化斑块检测方面的应用[J]. 基础医学与临床, 2022, 42(3): 360-365.
[10]	张爽, 李之凡, 钱杰, 吴娜琼. 腔内影像学方法评价降脂治疗对冠状动脉粥样硬化斑块影响的研究进展[J]. 基础医学与临床, 2022, 42(3): 366-371.
[11]	张琦悦, 张伟丽. 血管老化在动脉粥样硬化中的研究进展[J]. 基础医学与临床, 2022, 42(3): 372-377.
[12]	赵川榕, 周菁. 靶向剪切力敏感关键分子的动脉粥样硬化防治研究[J]. 基础医学与临床, 2022, 42(3): 378-383.
[13]	郑玲, 陈立, 王月. 白藜芦醇减轻脂多糖诱导的小鼠心脏损伤[J]. 基础医学与临床, 2022, 42(12): 1867-1872.
[14]	生燕, 李秀毛, 郭欣, 谢仟, 黄仁杰, 生欣. 兔颈动脉血流灌注减少促进血管内皮细胞炎性反应[J]. 基础医学与临床, 2021, 41(9): 1247-1252.
[15]	张传西, 张宇, 郭莎莎, 厉菁, 袁义强, 王明杰. 血清miR-181b和miR-27a表达与颈动脉粥样硬化程度相关[J]. 基础医学与临床, 2021, 41(8): 1133-1138.