Asprosin在生殖细胞发育中作用的研究进展

doi:10.16352/j.issn.1001-6325.2024.04.0558

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (4): 558-561.doi: 10.16352/j.issn.1001-6325.2024.04.0558

Asprosin在生殖细胞发育中作用的研究进展

徐志琴, 谭晓^*

南京医科大学第二附属医院心血管内科,江苏南京 210011

收稿日期:2023-09-15 修回日期:2023-12-27 出版日期:2024-04-05 发布日期:2024-03-25
通讯作者: ^*1114040139@qq.com
基金资助:
南京市医学科技发展项目(YKK14179)

Research progress on the role of Asprosin in germ cell development

XU Zhiqin, TAN Xiao^*

Department of Cardiology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China

Received:2023-09-15 Revised:2023-12-27 Online:2024-04-05 Published:2024-03-25
Contact: ^*1114040139@qq.com

摘要/Abstract

摘要： Asprosin是由140个氨基酸组成的蛋白类激素,主要由白色脂肪组织分泌。多囊卵巢综合征(PCOS)和精子无力症是影响生育的常见疾病。Asprosin通过促进卵泡刺激素(LH)诱导小颗粒细胞雌二醇的生成和胰岛素样生长因子1(IGF-1)诱导小颗粒细胞孕酮的生成等方式调节卵巢内卵泡的生长和优势卵泡排卵。Asprosin作用于下丘脑和睾丸,调节性激素的合成和促进生殖细胞对营养物质的摄取,增加精子的数量、存活率和运动能力。Asprosin参与调节卵泡的生长和精子的发生,为不育症的治疗提供新的策略和靶点。

关键词: Asprosin, 多囊卵巢综合征(PCOS), 生殖细胞

Abstract: Asprosin is a protein-like hormone composed of 140 amino acids, which is mainly secreted by adipocytes. Polycystic ovary syndrome(PCOS) and asthenospermia are common causes of infertility. Asprosin promotes the production of estradiol in small granular cells induced by follicle stimulating hormone(FSH )and progesterone in small granular cells induced by insulin-like growth factor 1(IGF-1), which functions in the growth of ovarian follicles and ovulation of dominant follicles. Asprosin promotes the secretion of sex hormones and the production of nutrients, increasing the number, survival time and motility of sperms by acting on the hypothalamus and testicles. Asprosin is involved in regulation of follicle growth and spermatogenesis, so this finding may potentially support the development of new strategies for the treatment of infertility.

Key words: Asprosin, polycystic ovary syndrome(PCOS), germ cell

中图分类号:

徐志琴, 谭晓. Asprosin在生殖细胞发育中作用的研究进展[J]. 基础医学与临床, 2024, 44(4): 558-561.

XU Zhiqin, TAN Xiao. Research progress on the role of Asprosin in germ cell development[J]. Basic & Clinical Medicine, 2024, 44(4): 558-561.

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Asprosin在生殖细胞发育中作用的研究进展

Research progress on the role of Asprosin in germ cell development

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