代谢组学在重伤诊治中的研究进展

doi:10.16352/j.issn.1001-6325.2024.04.0562

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (4): 562-567.doi: 10.16352/j.issn.1001-6325.2024.04.0562

代谢组学在重伤诊治中的研究进展

魏斌^1,2, 段红杰¹, 柴家科^1*

1.中国人民解放军总医院第四医学中心烧伤整形医学部,北京 100048;
2.中国人民武装警察部队北京总队医院外一科,北京 100027

收稿日期:2023-10-09 修回日期:2023-12-27 出版日期:2024-04-05 发布日期:2024-03-25
通讯作者: ^*cjk304@126.com

Research progress of metabolomics in the diagnosis and treatment of severe injuries

WEI Bin^1,2, DUAN Hongjie¹, CHAI Jiake^1*

1. Department of Burns and Plastic Surgery, the Fourth Medical Center of Chinese People's Liberation Army(PLA) General Hospital, Beijing 100048;
2. the First Department of Surgery, Chinese People's Armed Police Force Hospital of Beijing,Beijing 100027, China

Received:2023-10-09 Revised:2023-12-27 Online:2024-04-05 Published:2024-03-25
Contact: ^*cjk304@126.com

摘要/Abstract

摘要： 代谢组学是危重病和创伤研究的一个新兴领域,是近年来广泛用于疾病代谢紊乱的基因解析、分子标志物筛选和诊断等方面的一种重要研究方法。本篇综述总结和概括了国内外近年来创伤性脑损伤、外伤失血性休克以及严重烧伤等重伤诊治的代谢组学最新研究进展,阐述了利用代谢组学技术实时监测重伤患者伤后不同阶段的代谢变化,发现重症临床诊治不同的新靶点和生物标志物,优化临床实践中的诊治策略;展望了对烧冲复合伤的当前代谢组学研究问题和挑战,以及多组学技术和人工智能算法的同步发展,推动精准医学的发展。

关键词: 代谢组学, 创伤, 烧伤, 烧冲复合伤

Abstract: Metabolomics is a novel emerging technology recently applied in management of severe diseases and trauma, and has been widely used in gene analysis of disease metabolic disorders, clinical biomarker screening and disease diagnosis. This review comprehensively summarizes the latest research progress of the metabolomics in severe trauma and burns recently like traumatic brain injury(TBI), traumatic hemorrhagic shock, severe burns and so on. The paper elaborates the metabolomic technology which can quickly reflect the real-time metabolic changes of severely injured patients at different stages after injury, and uncovers new clinical biomarkers and potential drug targets of the patients with severe injuries thus improves the diagnosis and treatment strategies. Finally, we look forward to the current metabolomics research projects and tackling challenges on the burn-blast combined injuries, and the simultaneous development of multi-omics technology as well as artificial intelligence algorithms, which promotes the development of precision medicine.

Key words: metabolomics, trauma, burn, burn-blast combined injury

中图分类号:

:R605.971

魏斌, 段红杰, 柴家科. 代谢组学在重伤诊治中的研究进展[J]. 基础医学与临床, 2024, 44(4): 562-567.

WEI Bin, DUAN Hongjie, CHAI Jiake. Research progress of metabolomics in the diagnosis and treatment of severe injuries[J]. Basic & Clinical Medicine, 2024, 44(4): 562-567.

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代谢组学在重伤诊治中的研究进展

Research progress of metabolomics in the diagnosis and treatment of severe injuries

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