基础医学与临床 ›› 2023, Vol. 43 ›› Issue (11): 1655-1661.doi: 10.16352/j.issn.1001-6325.2023.11.1655

• 研究论文 • 上一篇    下一篇

心血管疾病高危人群的影响因素及其关联分析

沈霞芬1, 蔡强1, 俞蔚2*, 许晓辉1   

  1. 1.浙江清华长三角研究院 食品与健康研究所 风险评估实验室,浙江 嘉兴 314006;
    2.浙江医院 心血管内科,浙江 杭州 310013
  • 收稿日期:2023-04-18 修回日期:2023-07-18 出版日期:2023-11-05 发布日期:2023-10-30
  • 通讯作者: *yuweipost@163.com
  • 基金资助:
    浙江省医药卫生重大科技计划(WKJ-ZJ-1808)

Influencing factors and correlation analysis of population with high risk of cardiovascular diseases

SHEN Xiafen1, CAI Qiang1, YU Wei2*, XU Xiaohui1   

  1. 1. Risk Assessment Laboratory,Food and Health Research Institute,Yangtze Delta Region Institute of Tsinghua University,Jiaxing 314006;
    2. Department of Cardiovascular Medicine,Zhejiang Hospital,Hangzhou 310013,China
  • Received:2023-04-18 Revised:2023-07-18 Online:2023-11-05 Published:2023-10-30
  • Contact: *yuweipost@163.com

摘要: 目的 突出一些行为与非行为因素对心血管健康、疾病预防和管理方面的影响。方法 以浙江省20 745名心血管高危人群为研究对象,采用Cox回归及森林图评估和展现其行为和非行为因素与心血管疾病(CVD)风险的关系。针对至少存在一种最大风险行为因素的人群,采用Apriori算法分析其行为与非行为因素之间的关联。结果 浙江省心血管高危人群的发病率与年龄段呈正比,与受教育程度呈反比,男性风险高于女性,城市人群高于农村;发病率与吸烟强度成正比,与酒精摄入量呈现U型关联;工作以站立为主的人群发病率最低;在农业劳动者中有明显农忙和农闲之分的人群风险较低;从事一般体力劳动,且从不吸烟,也不大量饮酒的男性人群发病率较低。不吸烟、不喝酒的女性,在家无工作是心血管风险率较高的重要因素。结论 影响心血管疾病高危人群的危险因素较广,且各因素之间存在一定的关联性。

关键词: 心血管疾病, 高危人群, 行为因素, Cox回归, Apriori算法

Abstract: Objective To highlight the impact of behavioral and non-behavioral factors on cardiovascular health, disease prevention and management. Methods Cox regression and forest plots were used to assess and demonstrate the relationship between their behavioral and non-behavioral factors and cardiovascular disease (CVD) risk in a study population of 20 745 people at high cardiovascular risk from Zhejing province. Apriori algorithm was used to analyze the correlation between behavioral factors and non-behavioral factors for people with at least one of the greatest risk behavioral factors. Results The incidence of cardiovascular risk in Zhejiang province was positively related to age and inversely related to education level of target population. The higher risk was identified in in male and population in urban citities as compared to female and the people in rural areas; The risk was positively related to smoking intensity and showed a U-shaped association with alcohol intake; The incidence was lowest in those who were mainly standing during routine work; The risk was lower in those who had a clear distinction between busy and idle farming activity in farmers; Men who were engaged in general physical labor and never smoked nor drank high dose of alcohol; Women who never smoked and drank, but did not work and at home were important factors related to the higher cardiovascular risk rate. Conclusions There are a wide range of factors affecting the high-risk population of cardiovascular disease, and there is a certain correlation among these factors.

Key words: cardiovascular disease, high risk group, behavioral factor, Cox regression, apriori algorithm

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