免疫检查点CD276蛋白参与肿瘤发生发展作用机制的研究进展

doi:10.16352/j.issn.1001-6325.2023.07.1143

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (7): 1143-1147.doi: 10.16352/j.issn.1001-6325.2023.07.1143

免疫检查点CD276蛋白参与肿瘤发生发展作用机制的研究进展

陈忠婕, 黄嘉如, 胡清, 赵珍琴, 陈俏俏, 孙浚源, 贾静^*

杭州医学院检验医学院、生物工程学院,浙江杭州 310053

收稿日期:2022-08-20 修回日期:2023-03-16 发布日期:2023-07-05
通讯作者: ^*jiajingzjams@163.com
基金资助:
国家自然科学基金(81802622); 浙江省自然科学基金(LY18H160067)

Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development

CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing^*

School of Laboratory Medicine and Bioengineering, Hangzhou Medical College, Hangzhou 310053, China

Received:2022-08-20 Revised:2023-03-16 Published:2023-07-05

摘要/Abstract

摘要： 免疫检查点CD276,B7分子家族成员,可与磷脂酰肌醇3激酶/蛋白激酶B(PI3K/AKT)等信号通路相互作用,调控肿瘤能量代谢,抑制免疫细胞抗肿瘤活性,促肿瘤血管新生,帮助肿瘤免疫逃逸与肿瘤转移。CD276与肿瘤干性及化学治疗耐药密切相关。迄今若干以CD276为靶点的抗体类药物及细胞治疗方法已经进入临床试验。CD276还可作为肿瘤标志物用于肿瘤的诊断和分型。CD276的调控机制有非编码RNA、转录因子介导的转录水平调控,甲基化、糖基化等介导的翻译后修饰水平调控。

关键词: CD276, 肿瘤免疫逃逸, 肿瘤病理机制, 肿瘤免疫治疗, 免疫检查点

Abstract: The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation.

Key words: CD276, tumor immune escape, tumor pathological mechanism, tumor immunotherapy, immune checkpoint

中图分类号:

R730.3

陈忠婕, 黄嘉如, 胡清, 赵珍琴, 陈俏俏, 孙浚源, 贾静. 免疫检查点CD276蛋白参与肿瘤发生发展作用机制的研究进展[J]. 基础医学与临床, 2023, 43(7): 1143-1147.

CHEN Zhongjie, HUANG Jiaru, HU Qing, ZHAO Zhenqin, CHEN Qiaoqiao, SUN Junyuan, JIA Jing. Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development[J]. Basic & Clinical Medicine, 2023, 43(7): 1143-1147.

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免疫检查点CD276蛋白参与肿瘤发生发展作用机制的研究进展

Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development

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