神经干细胞移植治疗阿尔兹海默病的机制研究进展

doi:10.16352/j.issn.1001-6325.2023.07.1148

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (7): 1148-1151.doi: 10.16352/j.issn.1001-6325.2023.07.1148

神经干细胞移植治疗阿尔兹海默病的机制研究进展

陈小坤, 包新杰^*, 高俊, 李永宁^*

中国医学科学院北京协和医学院北京协和医院神经外科,北京 100730

收稿日期:2023-04-17 修回日期:2023-05-23 出版日期:2023-07-05 发布日期:2023-07-05
通讯作者: ^*liyongning@pumch.cn; baoxinjie@pumch.cn
基金资助:
国家自然科学基金(82170799, 82171475)

An update on the mechanism of neural stem cell transplantation in the treatment of Alzheimer’s disease

CHEN Xiaokun, BAO Xinjie^*, GAO Jun, LI Yongning^*

Department of Neurosurgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China

Received:2023-04-17 Revised:2023-05-23 Online:2023-07-05 Published:2023-07-05

摘要/Abstract

摘要： 目前并无有效的策略可以减缓阿尔茨海默病(AD)的进展。加深对AD发病机制的理解和研发新的治疗方法至关重要。干细胞移植治疗神经退行性疾病是目前的研究热点。许多研究认为神经干细胞(NSCs)可以分化成功能性神经元,可以替代原有死亡的神经元,并与相邻的残存神经元形成突触连接,从而达到疾病治疗作用。理论上,利用NSCs替换和恢复受损的乙酰胆碱能神经元和突出连接,可能为AD提供新的治疗选择。本文回顾了近期的临床前研究,总结了NSCs移植在AD治疗中的机制进展。

关键词: 阿尔茨海默病, 细胞移植, 神经干细胞

Abstract: At present, no effective strategy exists to slow down the progression of Alzheimer’s disease (AD). A deeper understanding of the pathogenesis of AD and the development of new therapeutic approaches are essential. Stem cell transplantation for the treatment of neurodegenerative diseases is currently a research hotspot. Numerous studies have suggested that neural stem cells (NSCs) can differentiate into functional neurons, replace dead neurons, and form synaptic connections with adjacent surviving neurons, thereby achieving a therapeutic effect. In theory, the use of NSCs to replace and restore damaged cholinergic neurons and synapses may provide a new therapeutic option for AD. This review summarizes the recent preclinical research progress of NSC transplantation for the treatment of AD.

Key words: Alzheimer’s disease, cell transplantation, neural stem cells

中图分类号:

R741.05

陈小坤, 包新杰, 高俊, 李永宁. 神经干细胞移植治疗阿尔兹海默病的机制研究进展[J]. 基础医学与临床, 2023, 43(7): 1148-1151.

CHEN Xiaokun, BAO Xinjie, GAO Jun, LI Yongning. An update on the mechanism of neural stem cell transplantation in the treatment of Alzheimer’s disease[J]. Basic & Clinical Medicine, 2023, 43(7): 1148-1151.

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神经干细胞移植治疗阿尔兹海默病的机制研究进展

An update on the mechanism of neural stem cell transplantation in the treatment of Alzheimer’s disease

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