NT5C2在疾病及治疗中的研究进展

doi:10.16352/j.issn.1001-6325.2023.05.0852

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (5): 852-856.doi: 10.16352/j.issn.1001-6325.2023.05.0852

NT5C2在疾病及治疗中的研究进展

舒玲, 霍本念, 宋林^*

重庆医科大学附属儿童医院药学部,国家儿童健康与疾病临床医学研究中心儿童发育疾病研究教育部重点实验室儿科学重庆市重点实验室,重庆 400014

收稿日期:2022-03-14 修回日期:2022-06-29 出版日期:2023-05-05 发布日期:2023-04-26
通讯作者: ^*songlin@hospital.cqmu.edu.cn
基金资助:
国家自然科学基金(81900162)

Research progress of NT5C2 in disease and treatment

SHU Ling, HUO Bennian, SONG Lin^*

Department of Pharmacy, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China

Received:2022-03-14 Revised:2022-06-29 Online:2023-05-05 Published:2023-04-26
Contact: ^*songlin@hospital.cqmu.edu.cn

摘要/Abstract

摘要： NT5C2所编码的蛋白为细胞质5'-核苷酸酶Ⅱ(cN-Ⅱ),该酶具有催化核苷单磷酸酯去磷酸化作用,主要参与细胞内嘌呤核苷酸库的调节。高表达cN-Ⅱ mRNA与急性白血病(AL)患者预后较差有关,获得性NT5C2突变会阻碍DNA和巯鸟嘌呤核苷酸(TGN)结合物的形成,导致6-巯基嘌呤(6-MP)耐药。此外,NT5C2与2型糖尿病、精神分裂症等多种疾病的发生风险都具有关联性。

关键词: NT5C2, 胞质5'-核酸酶Ⅱ(cN-Ⅱ), 核苷类似物, 急性白血病(AL), 2型糖尿病

Abstract: Cytosolic 5'-nucleotidase Ⅱ(cN-Ⅱ), the protein encoded by NT5C2, can catalyze the dephosphory-lation of nucleoside monophosphate and is mainly involved in the regulation of purine nucleotide pool in cells. High expression of cN-Ⅱ mRNA is associated with poor prognosis of patients with acute leukemia (AL). Acquired NT5C2 mutation will hinder the formation of DNA and thioguanine nucleotide (TGN) conjugate, resulting in 6-mercaptpurine(6-MP) resistance. In addition, NT5C2 is a risk factor associated with type Ⅱ diabetes, schizophrenia and other diseases.

Key words: NT5C2, cytosolic 5'-nucleotidase Ⅱ(cN-Ⅱ), nucleoside analogue, acute leukemia(AL), type 2 diabetes

中图分类号:

Q915

舒玲, 霍本念, 宋林. NT5C2在疾病及治疗中的研究进展[J]. 基础医学与临床, 2023, 43(5): 852-856.

SHU Ling, HUO Bennian, SONG Lin. Research progress of NT5C2 in disease and treatment[J]. Basic & Clinical Medicine, 2023, 43(5): 852-856.

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NT5C2在疾病及治疗中的研究进展

Research progress of NT5C2 in disease and treatment

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