环状RNA核受体相互作用蛋白1对肿瘤发生发展的调控机制研究进展

doi:10.16352/j.issn.1001-6325.2023.05.0827

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (5): 827-832.doi: 10.16352/j.issn.1001-6325.2023.05.0827

环状RNA核受体相互作用蛋白1对肿瘤发生发展的调控机制研究进展

高欣, 于永波, 王海存, 姜兴明^*, 王志东

哈尔滨医科大学附属第二医院普通外科,黑龙江哈尔滨 150086

收稿日期:2022-03-22 修回日期:2022-06-29 出版日期:2023-05-05 发布日期:2023-04-26
通讯作者: ^*xmjiang@hrbmu.edu.cn
基金资助:
黑龙江省博士后科学基金(LBH-Q21023);黑龙江省自然科学基金(LH2020H058);湖北陈孝平科技发展基金(CXPJJH12000002-2020015)

Research progress on regulatory mechanisms of circular RNA nuclear receptor interacting protein 1 in tumor occurrence and development

GAO Xin, YU Yongbo, WANG Haicun, JIANG Xingming^*, WANG Zhidong

Department of General Surgery, the 2nd Affiliated Hospital of Harbin Medical University, Harbin 150086, China

Received:2022-03-22 Revised:2022-06-29 Online:2023-05-05 Published:2023-04-26
Contact: ^*xmjiang@hrbmu.edu.cn

摘要/Abstract

摘要： 环状RNA(circRNA)是一类广泛表达于真核细胞的单链共价闭合性非编码RNA分子。近来研究发现circRNA参与调控细胞增殖、分化、凋亡等生物学过程,是肿瘤发生发展的关键调节因子。环状RNA核受体相互作用蛋白1(circ_NRIP1)作为一种环状RNA,在诸多人类肿瘤中呈现异常表达并能够调控肿瘤增殖和侵袭迁移等恶性生物学行为。阐明circ_NRIP1在肿瘤发生发展中的调控机制,能够为肿瘤诊断和治疗指明新的方向。

关键词: 环状RNA, 环状RNA核受体相互作用蛋白1(circ_NRIP1), 肿瘤发生发展, 调控机制

Abstract: Circular RNA (circRNA) is a class of single-stranded covalently closed non-coding RNA molecules widely expressed in eukaryotic cells. Recent studies have found that circRNA has been involved in modulating biological processes such as cell proliferation, differentiation, and apoptosis so it is the key regulator of tumor occurrence and development. Circular RNA nuclear receptor interacting protein 1(circ_NRIP1), as a circular RNA, is abnormally expressed in various human cancers and potentially regulates malignant biological behaviors such as tumor proliferation, invasion and migration. Elucidating the regulatory mechanisms of circ_NRIP1 in tumor occurrence and development may provide a new strategy for tumor diagnosis and treatment.

Key words: circular RNA, circular RNA nuclear receptor interacting protein 1(circ_NRIP1), tumor occurrence and development, regulatory mechanism

中图分类号:

R730

高欣, 于永波, 王海存, 姜兴明, 王志东. 环状RNA核受体相互作用蛋白1对肿瘤发生发展的调控机制研究进展[J]. 基础医学与临床, 2023, 43(5): 827-832.

GAO Xin, YU Yongbo, WANG Haicun, JIANG Xingming, WANG Zhidong. Research progress on regulatory mechanisms of circular RNA nuclear receptor interacting protein 1 in tumor occurrence and development[J]. Basic & Clinical Medicine, 2023, 43(5): 827-832.

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环状RNA核受体相互作用蛋白1对肿瘤发生发展的调控机制研究进展

Research progress on regulatory mechanisms of circular RNA nuclear receptor interacting protein 1 in tumor occurrence and development

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