单细胞RNA测序技术在主动脉扩张性疾病中的应用

doi:10.16352/j.issn.1001-6325.2022.07.1139

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (7): 1139-1143.doi: 10.16352/j.issn.1001-6325.2022.07.1139

单细胞RNA测序技术在主动脉扩张性疾病中的应用

郑凯, 任华亮, 张望德, 李春民^*

首都医科大学附属北京朝阳医院血管外科,北京 100020

收稿日期:2021-08-26 修回日期:2022-01-07 出版日期:2022-07-05 发布日期:2022-06-29
通讯作者: * lcmbs@126.com
基金资助:
吴阶平医学基金会临床科研专项资助基金(320.6750.18550)

Application of single-cell RNA sequencing technologies in aortic dilatation diseases

ZHENG Kai, REN Hua-liang, ZHANG Wang-de, LI Chun-min^*

Department of Vascular Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020,China

Received:2021-08-26 Revised:2022-01-07 Online:2022-07-05 Published:2022-06-29
Contact: * lcmbs@126.com

摘要/Abstract

摘要： 主动脉扩张性疾病以主动脉夹层和主动脉瘤为代表,是血管外科最危险的疾病,该疾病的发病机制尚不十分明确。单细胞RNA测序(scRNA-seq)技术能在单个细胞水平研究细胞异质性,识别新的细胞状态和群体,为研究主动脉疾病的发生和发展机制提供了一种新工具。

关键词: 主动脉疾病, 单细胞RNA测序, 单细胞转录组测序, 高通量RNA测序

Abstract: Aortic dilation disease, represented by aortic dissection and aortic aneurysm, is the most dangerous disease in vascular surgery. The pathogenesis of this disease is not very clear. Single-cell RNA sequencing (scRNA-seq) technology can study cell heterogeneity and identify new cell states and populations at the single cell level, which provides a new tool for studying the occurrence and development mechanism of aortic disease.

Key words: aortic disease, single-cell RNA sequencing, single-cell transcriptome sequencing, high throughput RNA sequencing

中图分类号:

郑凯, 任华亮, 张望德, 李春民. 单细胞RNA测序技术在主动脉扩张性疾病中的应用[J]. 基础医学与临床, 2022, 42(7): 1139-1143.

ZHENG Kai, REN Hua-liang, ZHANG Wang-de, LI Chun-min. Application of single-cell RNA sequencing technologies in aortic dilatation diseases[J]. Basic & Clinical Medicine, 2022, 42(7): 1139-1143.

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单细胞RNA测序技术在主动脉扩张性疾病中的应用

Application of single-cell RNA sequencing technologies in aortic dilatation diseases

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