Predictive value of preoperative MRI enhancement features on postoperative recurrent time in recurrent glioblastoma patients

doi:10.3969/j.issn.1672-6731.2019.12.008

Abstract

Abstract:

Objective To analyze the relationship between preoperative enhanced MRI manifestation and recurrent time of recurrent glioblastoma, and to explore the predictive value of imaging signs for recurrence time. Methods A total of 36 patients with pathologically confirmed glioblastoma were collected from February 2012 to April 2017. All patients underwent preoperative and postoperative T₁WI and enhanced MRI scans, and enhanced cross-sections and sagittal or coronary scans were performed. Manually measure the volume of the lesion-enhanced and non-enhanced necrotic areas on the enhanced MRI image. The totality was divided into 2 groups according to the percentage of necrosis that accounts for the entire tumor volume. Necrosis in group A accounts for > 50% of the total tumor volume, and necrosis in group B accounts for < 50% of the total tumor volume. Analyze the enhanced MRI features before surgery, the time of first recurrence, MRI manifestations and overall survival (OS). Results The recurrence time in group A was significantly shorter than that in group B[(6.00 ±0.99) months vs. (9.00 ±1.49) months, P=0.049]. Necrotic-based glioblastomas recurred faster. When stratifying patients in group A and group B based on clinical characteristics, the recurrence time of patients in group A was still significantly shorter than that in group B in the group of age < 65 years old and receiving radiotherapy and chemotherapy[6 (3, 8) months vs. 9 (6, 13) months, 6 (6, 10) months vs. 12 (3, 24) months; P<0.05, for all]. Conclusions Preoperative enhanced MRI findings have predictive value for postoperative recurrence in patients with glioblastoma who are younger than 65 years old and receive radiotherapy and chemotherapy.

Key words: Glioblastoma, Recurrence, Magnetic resonance imaging

摘要：

目的分析胶质母细胞瘤患者术前MRI强化特征与术后复发时间的关系，探讨影像学征象对术后复发时间的预测价值。方法收集2012年2月至2017年4月经组织病理证实的36例胶质母细胞瘤患者手术前后T₁WI平扫和增强扫描资料，手动测量增强MRI图像上病灶强化区和无强化坏死区体积，根据坏死区所占整个瘤体体积百分比进行结构测量（A组坏死区所占比例 > 50%，B组实性区所占比例 > 50%），分析两组患者术前MRI强化特征、术后首次复发时间、MRI表现及总生存期的特点。结果 A组患者术后复发时间短于B组患者[（6.00 ±0.99）个月对（9.00 ±1.49）个月，P=0.049]，以坏死类型为主的胶质母细胞瘤患者术后复发时间更早。基于临床特征对A组和B组患者进行分层，在年龄<65岁、接受放化疗分层中，A组患者复发时间仍短于B组患者[6（3，8）个月对9（6，13）个月、6（6，10）个月对12（3，24）个月，均P<0.05]。结论术前增强MRI病灶类型和表现，对年龄 < 65岁、接受放化疗的胶质母细胞瘤患者的术后复发时间具有预测价值。

关键词: 胶质母细胞瘤, 复发, 磁共振成像

SONG Kun, QIN Zhi-yong, XU Hao, QIU Tian-ming, CHENG Ai-lan, CHU Shu-guang. Predictive value of preoperative MRI enhancement features on postoperative recurrent time in recurrent glioblastoma patients[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2019, 19(12): 954-957.

宋昆, 秦智勇, 徐浩, 邱天明, 程爱兰, 初曙光. 复发胶质母细胞瘤患者术前MRI强化特征对术后复发时间的预测价值[J]. 中国现代神经疾病杂志, 2019, 19(12): 954-957.

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URL: https://journal11.magtechjournal.com/cjcnn/EN/10.3969/j.issn.1672-6731.2019.12.008

https://journal11.magtechjournal.com/cjcnn/EN/Y2019/V19/I12/954

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