Abstract: From June 2005 to October 2012, there were 135 cases with cerebrospinal fluid (CSF) rhinorrhea admitted in our hospital who underwent nasal endoscopic repair surgery, and intracranial infection happened in 3 cases after surgery, including intracranial mucormycosis in one case, brain abscess in one case and bacterial infection in one case. These 3 cases underwent surgery to clear up the focus of infection, supplemented by antifungal drugs or antibiotic therapy. Case 1 and Case 2 were followed up for 2 years without CSF rhinorrhea or intracranial infection; Case 3 died due to multiple organ failure. The intracranial complications after nasal endoscopic surgery for repairing CSF leakage are rare and need combined treatment of relevant departments.

Key words: Cerebrospinal fluid rhinorrhea, Endoscopy, Central nervous system infections

摘要： 共135 例术后并发脑脊液鼻漏患者中3 例发生颅内感染，分别为毛霉菌感染（1 例）、脑脓肿（1 例）和细菌感染（1 例）。经感染灶清除术辅助抗真菌药物或抗生素治疗，随访2 年，2 例脑脊液鼻漏或颅内感染未复发、1 例因多脏器衰竭死亡。鼻内镜脑脊液鼻漏修补术后发生颅内并发症罕见，需要相关科室协作共同治疗。

关键词: 脑脊液鼻漏, 内窥镜检查, 中枢神经系统感染