Abstract: Deep brain stimulation (DBS), an important form of neuromodulation therapy, provides a new treatment option for drug -resistant epilepsy (DRE) patients through precisely selections the stimulation target. By implanting electrodes at specific targets and releasing electrical stimulation, DBS can regulate the excitability of the relevant nuclei and neural circuits in the process of seizure, so as to exert the effect of controlling seizure. At present, some clinical and laboratory evidence has been accumulated on the regulatory mechanism of DBS in the treatment of DRE, the individualized selection of stimulation targets for different types of seizures, the curative effect and adverse events. This article will elaborate the above three aspects, in an effort to promote the application of DBS in DRE.

Key words: Drug resistant epilepsy, Deep brain stimulation, Review

摘要： 脑深部电刺激术作为神经调控疗法的重要形式，通过精准选择刺激靶点为耐药性癫痫患者提供新的治疗选择。其可以通过在特定靶点植入电极并发放电刺激，对癫痫发作过程中相关神经核团及神经回路兴奋性进行调控，从而发挥控制癫痫发作的功效。目前脑深部电刺激术治疗耐药性癫痫的调控机制、不同发作类型个体化刺激靶点选择、临床疗效与安全性等积累了一定的临床和实验室证据，本文拟就上述三方面进行阐述，以促进脑深部电刺激术在耐药性癫痫领域的应用。

关键词: 耐药性癫痫, 深部脑刺激法, 综述