Research progress of essential tremor‐Parkinson's disease

doi:10.3969/j.issn.1672-6731.2022.04.004

Abstract

Abstract: Essential tremor (ET) and Parkinson's disease (PD) are two common movement disorders. A large number of clinical evidence found that a part of patients with early diagnosis of ET could evolve into PD. These patients are diagnosed with essential tremor-Parkinson's disease (ET-PD). However, there is a lack of diagnostic criteria for ET - PD, and the overlap of clinical symptoms of ET and PD makes the identification of ET - PD challenging. Here, with an aim to improve the levels of clinical diagnosis and treatment, we summarize the research progress of ET-PD in epidemiology, clinical characteristics, pathology and pathophysiology, electrophysiological characteristics, neuroimaging characteristics, genetics and treatment in order to improve the level of clinical diagnosis and treatment.

Key words: Essential tremor, Parkinson disease, Review

摘要： 特发性震颤和帕金森病是两种常见的运动障碍性疾病,部分最初诊断为特发性震颤的患者可进展为帕金森病,称为特发性震颤发展为帕金森病(ET-PD),但目前尚未达成ET-PD的诊断共识。特发性震颤与帕金森病临床症状的重叠使得ET-PD的诊断充满挑战。本文综述ET-PD流行病学、临床特点、病理学与病理生理学、神经电生理学、神经影像学、遗传学和治疗等方面进展,以提高临床诊断与治疗水平。

关键词: 特发性震颤, 帕金森病, 综述

ZUO Qi, ZHENG Qian, JIAO Ling, FENG Zhan-hui, HE Dian. Research progress of essential tremor‐Parkinson's disease[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(4): 237-242.

左琦, 郑乾, 焦玲, 冯占辉, 贺电. 特发性震颤发展为帕金森病研究进展[J]. 中国现代神经疾病杂志, 2022, 22(4): 237-242.

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https://journal11.magtechjournal.com/cjcnn/EN/Y2022/V22/I4/237

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