Chinese Journal of Contemporary Neurology and Neurosurgery ›› 2022, Vol. 22 ›› Issue (4): 229-236. doi: 10.3969/j.issn.1672-6731.2022.04.003

• Special Review • Previous Articles     Next Articles

Progression of respiratory disorders associated with Parkinson's disease

TIAN Min, LIU Yi-ming   

  1. Department of Neurology, Qilu Hospital of Shandong University, Ji'nan 250012, Shandong, China
  • Received:2022-03-28 Online:2022-04-25 Published:2022-05-05
  • Supported by:
    This study was supported by the National Natural Science Foundation of China (No. 81771373, 82171245).

帕金森病相关呼吸功能障碍研究进展

田敏, 刘艺鸣   

  1. 250012 济南, 山东大学齐鲁医院神经内科
  • 通讯作者: 刘艺鸣, Email:liuym@sdu.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(项目编号:81771373);国家自然科学基金资助项目(项目编号:82171245)

Abstract: Parkinson's disease (PD), a common degenerative disease of the central nervous system, can affect the respiratory system. Pulmonary complications remain its leading cause of death, but the pathogenesis and its relationship to the severity of motor symptoms and non - motor symptoms, medication, and disease phenotype in PD have not been fully elucidated. This article reviews the advances in research on the anatomical and physiological basis, the disease itself and treatment- related respiratory disturbances to deepen the understanding of respiratory dysfunction associated with PD and to provide new insights for treatment.

Key words: Parkinson disease, Respiration disorders, Levodopa, Deep brain stimulation, Review

摘要: 帕金森病是临床常见的神经系统变性疾病,可累及呼吸系统,其相关呼吸系统并发症是主要死因,但发病机制及其与帕金森病运动症状和非运动症状严重程度、药物治疗及疾病表型等关系尚未完全阐明。本文综述解剖生理学基础、疾病自身和治疗相关呼吸功能障碍等研究进展,以加深对帕金森病相关呼吸功能障碍的认识,为疾病治疗提供新的思路。

关键词: 帕金森病, 呼吸障碍, 左旋多巴, 深部脑刺激法, 综述