Abstract:

Essential tremor (ET) is the most common movement disorder. In recent years, there has been no breakthrough of drug therapy. Therefore, surgical methods have played an important role in the treatment of ET patients with ineffective drug treatment. Magnetic resonance-guided focused ultrasound (MRgFUS) has been increasingly researched and applied in the treatment of ET as a good replacement therapy of surgeries, because it has such advantages as noninvasiveness, non-ionizing radiation, and intraoperative real-time monitoring of target temperature and morphology. The development history of MRgFUS treatment in ET, treatment principles, target selection, clinical efficacy, side effects, comparison with other surgical methods, deficiencies and prospects were briefly reviewed in this article.

Key words: Essential tremor, Magnetic resonance imaging, Ultrasonic therapy, Review

摘要：

特发性震颤是临床常见运动障碍性疾病，药物治疗虽为其首选方法，但难以有效控制病情进展，外科手术是目前重要的替代治疗选择。其中，磁共振引导下聚焦超声以其无创性、无电离辐射、可于术中实时监测治疗靶点温度和形态等优势成为良好的替代外科治疗方法，通过对其发展史、治疗原理、治疗靶点的选择、治疗效果、不良反应等方面研究进展的综述，有助于全面评价其临床应用价值。

关键词:  特发性震颤, 磁共振成像, 超声疗法, 综述