Abstract:

The perihematomal edema (PHE) after intracerebral hemorrhage (ICH) is one of the manifestations of secondary brain injury. It is generally believed that the formation of PHE is due to the destruction of blood-brain barrier (BBB) after ICH, which in turn leads to the formation of vasogenic edema. At present, the methods for quantitatively evaluating the permeability of BBB include imaging evaluation and biological marker evaluation, both of which can be used as an important way to study the relationship between BBB and PHE. The ultimate goal of studying the relationship between BBB destruction and PHE is to find treatments that can prevent BBB destruction and reduce PHE after ICH.

Key words: Cerebral hemorrhage, Blood-brain barrier, Edema, Review

摘要：

脑出血后血肿周围水肿的形成是继发性脑组织损害的表现形式之一。普遍认为血肿周围水肿的形成是由于脑出血后血-脑屏障破坏，进而引发血管源性水肿。目前定量评价血-脑屏障通透性的方法包括影像学和生物学标志物，二者均可以作为研究血-脑屏障与血肿周围水肿关系的重要方法。研究血-脑屏障破坏与血肿周围水肿之间关系的最终目的是探寻到可以阻止血-脑屏障破坏、减少血肿周围水肿的治疗方法。

关键词: 脑出血, 血脑屏障, 水肿, 综述