Abstract:

Dorsal root ganglia (DRG) neurons are the primary afferent neurons of algaesthesis of trunk and extremities. DRG transmits and accommodates sensations and accepts and conveys nociception, so it plays an important role in the mechanism of pain. DRG is accessible to clinical interventions for the control of intractable pain and is a target for neuromodulation therapy. This review focuses on sodium ion channels in DRG, glial cells and inflammatory reaction which are mainly involved in the mechanism of pain.

Key words: Ganglia, spinal, Pain, Review

摘要：

背根神经节神经元是躯干、四肢痛觉的初级传入神经元，具有传输和调节机体感觉、接受和传导伤害性感受的功能，在疼痛机制中发挥重要作用。临床以背根神经节为靶点的介入治疗和神经调节治疗可以缓解疼痛。本文拟就背根神经节的钠离子通道、胶质细胞和炎症反应在疼痛机制中的研究进展进行综述。

关键词: 神经节, 脊, 疼痛, 综述