Abstract: Five patients with sporadic Creutzfeldt-Jakob disease (sCJD) presented rapidly progressive dementia which were subacute onset from 1 to 4 months. Among these cases, periodic synchronous discharge (PSD) of electroencephalography (EEG) was seen in 2 patients. Besides, 4 patients obtained positive results in cerebrospinal fluid (CSF) analysis for 14-3-3 protein. The cranial MRI examination showed symmetrical or asymmetrical colored-ribbon-shaped high signals in cerebral cortex or basal ganglia by diffusion weighted imaging (DWI), suggesting that DWI had high sensitivity and specificity for the diagnosis of sCJD as a preferred method in the clinical examination of sCJD.

Key words: Creutzfeldt-Jakob syndrome, Diffusion magnetic resonance imaging

摘要： 散发型克-雅病患者共计5 例，临床主要表现为快速进展性痴呆，发病时间 1 ~ 4 个月。其中2 例脑电图呈现特征性周期性同步放电，4 例脑脊液14-3-3 蛋白检测阳性。MRI 扩散加权成像均显示皮质或基底节对称性或非对称性“彩带”样高信号，提示扩散加权成像对克? 雅病的诊断敏感且具有特异性，可作为临床首选检查方法。

关键词: 克-亚综合征, 磁共振成像, 弥散