Abstract:

Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease caused by prion protein infection. Compared with other neurodegenerative diseases, neuronal cell apoptosis in CJD occurs more rapidly. It has become increasingly evident that sleep dysfunction is commonly seen in chronic neurodegenerative conditions and may present several years before the disease onset. Therefore, understanding the relation of dyssomnia to CJD may enhance our realization of the relationship between sleep disorders and other common neurodegenerative diseases. More and more studies have shown that sleep disorders are very common in CJD patients. Thus, clinicians should regularly screen for sleep conditions in possible CJD patients to enhance the diagnosis and treatment of CJD.

Key words: Creutzfeldt-Jakob syndrome, Sleep disorders, Review

摘要：

Creutzfeldt-Jakob 病系指朊病毒感染导致的致死性神经变性病，其神经细胞凋亡速度较其他神经变性病更迅速。睡眠障碍常见于慢性神经变性病，且可能早于疾病发生前数年出现。了解睡眠障碍与Creutzfeldt-Jakob 病的关系，可以提高临床医师对睡眠障碍与其他常见神经变性病关系的理解。Creutzfeldt-Jakob 病合并睡眠障碍较为常见，应定期筛查可能的Creutzfeldt-Jakob 病患者睡眠状况，有助于疾病的诊断与治疗。

关键词: 克-亚综合征, 睡眠障碍, 综述