Abstract: Magnesium is an important endogenous ion and coenzyme factor involved in many physiological processes, such as oxidative phosphorylation, glycolysis, gene transcription, protein synthesis, and is widely used in clinical practice. During recent years, continuous studies in magnesium ions with epilepsy suggest that magnesium can be used for the prevention and treatment of epilepsy, even for the supplemental treatment of refractory epilepsy. This article reviews the recent research progress from several aspects, such as relation between the low extracellular magnesium and epilepsy, abnormal magnesium concentration in the blood of epileptic patients, the antiepileptic effect of magnesium and possible mechanisms.

Key words: Magnesium, Anticonvulsants, Epilepsy, Review

摘要： 镁离子是一种重要的内源性离子和辅酶因子，参与体内诸如氧化磷酸化、糖酵解、基因转录、蛋白质合成等多种重要的生命活动，并在临床医疗实践中应用广泛。近年来，随着人类对镁离子与癫痫之间关系研究的不断深入，发现镁离子可以用于癫痫的预防与治疗，甚至有学者提出可以作为难治性癫痫的辅助治疗药物。本文对近年最新研究进展进行回顾，从细胞外低镁与癫痫的关系、癫痫患者血清镁离子异常、镁的抗癫痫作用及可能机制等几个方面进行综述。

关键词: 镁, 抗惊厥药, 癫痫, 综述