Abstract: Epilepsy is a common disease of nervous system, which is characterized by seizures resulting from abnormal, excessive or hypersynchronous neuronal activity in the brain. Molecular mechanism of epileptogenesis is always the focus of global neuroscientific researches. Epilepsy has various kinds of pathogenesis, with complicated molecular mechanism, involving ion channel, glutamatergic system, γ-aminobutyric acid (GABA) system, neurotrophic factor, inflammatory mediator and other relevant aspects. The article summarizes the molecular mechanism of epileptogenesis, further aiming to discover the new type of antiepileptic drugs (AEDs).

Key words: Epilepsy, Molecular biology, Review

摘要： 癫痫是神经系统常见疾病，以大量神经元反复发作异常放电引起的中枢神经系统短暂性功能失调为特征。对癫痫发生分子机制的研究一直是全球神经科学界关注的焦点。其病因多种多样、机制复杂，涉及离子通道、谷氨酸能系统、γ?氨基丁酸能系统、神经营养因子和炎性介质等多方面。本文拟对癫痫发病的分子机制进行综述，以为研制新型抗癫痫药物寻找新的线索和突破点。

关键词: 癫痫, 分子生物学, 综述