中国现代神经疾病杂志 ›› 2026, Vol. 26 ›› Issue (1): 92-98. doi: 10.3969/j.issn.1672-6731.2026.01.013

• 神经调控前沿理论与临床转化 • 上一篇    下一篇

2 经颅交流电刺激治疗抑郁症机制研究与应用进展

杨鑫1, 王书哲2, 李申3   

  1. 1. 300222 天津大学精神医学中心 天津大学医学院2025级;
    2. 300222 天津大学精神医学中心 天津大学医学院2024级;
    3. 300222 天津市安定医院神经调控诊疗中心
  • 收稿日期:2025-09-26 发布日期:2026-01-29
  • 通讯作者: 李申,Email:lishen@tmu.edu.cn
  • 基金资助:
    国家自然科学基金资助项目(项目编号:82371512);天津市卫生健康科技项目(项目编号:TJWJ2024MS037)

Mechanisms and clinical advances in transcranial alternating current stimulation for the treatment of depression

YANG Xin1, WANG Shu-zhe2, LI Shen3   

  1. 1 Grade 2025, School of Medicine, Tianjin University; Tianjin University for Mental Health, Tianjin 300222, China;
    2 Grade 2024, School of Medicine, Tianjin University; Tianjin University for Mental Health, Tianjin 300222, China;
    3 epartment of Brain Assessment & Intervention Laboratory, Tianjin Anding Hospital, Tianjin 300222, China
  • Received:2025-09-26 Published:2026-01-29
  • Supported by:
    This study was supported by the National Natural Science Foundation of China (No. 82371512), and Tianjin Health Research Project (No. TJWJ2024MS037).

摘要: 经颅交流电刺激作为一种非侵入性神经调控技术,通过特定频率的交流电与内源性神经振荡相互作用,调节神经元放电同步性,改善神经功能。近年该项技术在抑郁症的治疗中展现出潜力。本文综述不同类型经颅交流电刺激在抑郁症中的应用进展,探讨其优化策略及发展方向,为临床实践和临床研究提供参考。

关键词: 抑郁症, 电刺激疗法, 综述

Abstract: Transcranial alternating current stimulation (tACS) is a non-invasive neuromodulation technique that applies low -intensity sinusoidal currents at specific frequencies to interact with endogenous neural oscillations. By modulating neuronal firing synchrony, tACS can improve neural functions. In recent years, this technique has shown potential in the treatment of depression. This article reviews advances in the application of various tACS modalities in depression, discusses optimization strategies and future directions, and provides insights for clinical practice and further research.

Key words: Depressive disorder, Electric stimulation therapy, Review

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