我国脑肿瘤专病人脑组织资源库建设意义及进展

doi:10.3969/j.issn.1672-6731.2022.07.014

中国现代神经疾病杂志 ›› 2022, Vol. 22 ›› Issue (7): 635-640. doi: 10.3969/j.issn.1672-6731.2022.07.014

2 我国脑肿瘤专病人脑组织资源库建设意义及进展

王军成¹, 赵岳阳², 马东明¹

1 750001 银川, 宁夏回族自治区人民医院神经外科;
2 750001 银川, 宁夏回族自治区人民医院肿瘤科

收稿日期:2022-07-13 出版日期:2022-07-25 发布日期:2022-08-01
基金资助:
宁夏回族自治区自然科学基金资助项目（项目编号：2021AAC03313）；宁夏医科大学科学研究项目（项目编号：XM2020087）；宁夏回族自治区人民医院国家自然科学基金预实验项目（项目编号：2021GZRYSY017）；2021年第六批宁夏回族自治区青年科技人才托举工程

Significance and progress of the construction of human brain bank for the patients of brain tumors in China

WANG Jun-cheng¹, ZHAO Yue-yang², MA Dong-ming¹

1 Department of Neurosurgery, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750001, Ningxia, China;
2 Department of Oncology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750001, Ningxia, China

Received:2022-07-13 Online:2022-07-25 Published:2022-08-01
Contact: 马东明,Email:Madongming0506@163.com
Supported by:
This study was supported by Ningxia Hui Autonomous Region Natural Science Foundation (No. 2021AAC03313), Scientific Research Foundation of Ningxia Medical University (No. XM2020087), Pre-experiment Project of National Natural Science Foundation of People's Hospital of Ningxia Hui Autonomous Region (No. 2021GZRYSY017), and The Sixth Batch of Young Scientists and Technological Talents Promotion Project in Ningxia Hui Autonomous Region in 2021.

摘要/Abstract

摘要： 脑肿瘤尤其是恶性脑肿瘤的治疗已进入瓶颈期，传统分子生物学、细胞及动物实验在脑肿瘤治疗上再难有重大突破，研究热点重新转向人脑组织解剖学及病理学研究。但可供研究的人脑组织极其缺乏，鼓励脑肿瘤患者进行器官捐献、建立标准的脑肿瘤专病人脑组织资源库（简称脑库）对脑肿瘤治疗、脑科学研究具有重要意义。我国的脑库建设起步较晚，规模较小，发展仍相对缓慢，本文借鉴他国脑库建设经验，为我国脑库及脑肿瘤专病脑库建设及完善提供指导。

关键词: 脑肿瘤, 神经病理学, 尸体解剖, 人脑组织资源库(非MeSH词), 综述

Abstract: The treatment of brain tumors, especially the malignant brain tumors, has entered in the bottleneck period at present. It is difficult for traditional molecular biology, cell and animal experiments to make a major breakthrough in the treatment of brain tumors, so researchers have turned their attention to the anatomy and pathology of human whole brain tissue. However, the human whole brain tissue which is available for research is extremely deficient. It is of great significance to encourage brain tumors patients to donate organs and establish a standard human brain tissue resource bank of brain tumors (shortened to brain bank) for the research of brain science and providing new treatment ideas for brain tumors, while the construction of brain bank in China started late, with a relatively small scale and relatively slow development. This paper intends to provide guidance for the construction and improvement of brain bank and specific brain tumors related brain bank in China by drawing on the relevant experience of the construction of brain bank in other countries.

Key words: Brain neoplasms, Neuropathology, Autopsy, Human brain bank (not in MeSH), Review

王军成, 赵岳阳, 马东明. 我国脑肿瘤专病人脑组织资源库建设意义及进展[J]. 中国现代神经疾病杂志, 2022, 22(7): 635-640.

WANG Jun-cheng, ZHAO Yue-yang, MA Dong-ming. Significance and progress of the construction of human brain bank for the patients of brain tumors in China[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(7): 635-640.

https://journal11.magtechjournal.com/cjcnn/CN/Y2022/V22/I7/635

参考文献

[1] Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL, Barnholtz-Sloan JS. Brain and other central nervous system tumor statistics, 2021[J]. CA Cancer J Clin, 2021, 71:381-406.
[2] Zheng RS, Zhang SW, Zeng HM, Wang SM, Sun KX, Chen R, Li L, Wei WQ, He J. Cancer incidence and mortality in China, 2016[J]. J Natl Canc Cent, 2022, 2:1-9.
[3] Han RQ, Zhou JY, Zhang SW, Zeng HM, Wang SM, Chen R, Wei WQ, He J. Incidence and mortality of brain tumor in China, 2015[J]. Zhongguo Zhong Liu, 2021, 30:29-34.[韩仁强,周金意, 张思维, 曾红梅, 王少明, 陈茹, 魏文强, 赫捷. 2015年中国脑瘤发病与死亡分析[J]. 中国肿瘤, 2021, 30:29-34.]
[4] Mei F, Qiu RW, Mai YY, Chen SX, Liu SJ, Min XD, Yin ZH, Bao Y, Qi ST. History, status and prospect of pediatric brain tumors[J]. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi, 2020, 20:258-262.[梅芬, 邱若薇, 麦益颖, 陈舒娴, 刘思洁, 闵旭东,尹铸豪, 包赟, 漆松涛. 儿童脑肿瘤治疗历史、现状及展望[J]. 中国现代神经疾病杂志, 2020, 20:258-262.]
[5] Kang JH, Desjardins A. Convection-enhanced delivery for high-grade glioma[J]. Neurooncol Pract, 2021, 9:24-34.
[6] Reddy S, Tatiparti K, Sau S, Iyer AK. Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors[J]. Drug Discov Today, 2021, 26:1944-1952.
[7] Michalski JM, Janss AJ, Vezina LG, Smith KS, Billups CA, Burger PC, Embry LM, Cullen PL, Hardy KK, Pomeroy SL, Bass JK, Perkins SM, Merchant TE, Colte PD, Fitzgerald TJ, Booth TN, Cherlow JM, Muraszko KM, Hadley J, Kumar R, Han Y, Tarbell NJ, Fouladi M, Pollack IF, Packer RJ, Li Y, Gajjar A, Northcott PA. Children's oncology group phase Ⅲ trial of reduced-dose and reduced-volume radiotherapy with chemotherapy for newly diagnosed average-risk medulloblastoma[J]. J Clin Oncol, 2021, 39:2685-2697.
[8] Chemaitilly W, Armstrong GT, Gajjar A, Hudson MM. Hypothalamic-pituitary axis dysfunction in survivors of childhood CNS tumors:importance of systematic follow-up and early endocrine consultation[J]. J Clin Oncol, 2016, 34:4315-4319.
[9] Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. Challenges to curing primary brain tumours[J]. Nat Rev Clin Oncol, 2019, 16:509-520.
[10] Alghamri MS, McClellan BL, Avvari RP, Thalla R, Carney S, Hartlage CS, Haase S, Ventosa M, Taher A, Kamran N, Zhang L, Faisal SM, Núñez FJ, Garcia-Fabiani MB, Al-Holou WN, Orringer D, Hervey-Jumper S, Heth J, Patil PG, Eddy K, Merajver SD, Ulintz PJ, Welch J, Gao C, Liu J, Núñez G, Hambardzumyan D, Lowenstein PR, Castro MG. G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy[J]. Sci Adv, 2021, 7:eabh3243.
[11] Branter J, Estevez-Cebrero M, Diksin M, Griffin M, Castellanos-Uribe M, May S, Rahman R, Grundy R, Basu S, Smith S. Genome-wide expression and anti-proliferative effects of electric field therapy on pediatric and adult brain tumors[J]. Int J Mol Sci, 2022, 23:1982.
[12] Tamai S, Ichinose T, Tsutsui T, Tanaka S, Garaeva F, Sabit H, Nakada M. Tumor microenvironment in glioma invasion[J]. Brain Sci, 2022, 12:505.
[13] Pereira ELR, Feio DCA, Tavares JPL, Morikawa NM, Deus DF, Vital CG, Tavares ER, Maranhão RC. Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries:hypotheses for use in drug targeting therapy[J]. J Neurooncol, 2022, 158:413-421.
[14] Ketchen SE, Gamboa-Esteves FO, Lawler SE, Nowicki MO, Rohwedder A, Knipp S, Prior S, Short SC, Ladbury JE, Brüning-Richardson A. Drug resistance in glioma cells induced by a mesenchymal-amoeboid migratory switch[J]. Biomedicines, 2021, 10:9.
[15] Skowronski G, Ramnani A, Walton-Sonda D, Forlini C, O'Leary MJ, O'Reilly L, Sheahan L, Stewart C, Kerridge I. A scoping review of the perceptions of death in the context of organ donation and transplantation[J]. BMC Med Ethics, 2021, 22:167.
[16] Horn F. Evolution and medicine:the central role of anatomy[J]. Ann Anat, 2022, 239:151809.
[17] Tubbs RS. Anatomy, the eye of medicine[J]. Clin Anat, 2021, 34:821.
[18] Baldasare D. Linking organ donors and the medical/scientific research community:a US perspective[J]. Cell Tissue Bank, 2011, 12:3-35.
[19] Griffin CP, Paul CL, Alexander KL, Walker MM, Hondermarck H, Lynam J. Postmortem brain donations vs premortem surgical resections for glioblastoma research:viewing the matter as a whole[J]. Neurooncol Adv, 2021, 4:vdab168.
[20] Zhou JJ, Wu JS, Chen XC. Establishment of glioma tissue bank and clinical reasearch[J]. Zhongguo Lin Chuang Shen Jing Ke Xue, 2013, 21:238-240.[周佳菁, 吴劲松, 陈衔城. 胶质瘤组织库建立和临床研究探讨[J]. 中国临床神经科学, 2013, 21:238-240.]
[21] Fang C, Tan YL, Wang JL, Shi YF, Shan XS, Li W. Establishment and preliminary application of human glioma tissue bank[J]. Zhonghua Shi Yan Wai Ke Za Zhi, 2010, 27:1383.[方川, 檀艳丽, 王佳良, 史彦芳, 单小松, 李炜. 人脑胶质瘤组织库的建立及初步应用[J]. 中华实验外科杂志, 2010, 27:1383.]
[22] Jiao BH, Liang CH, Wang YY, Sun SA, Xi ZH. Establishment and management of gliomas tissues bank[J]. Hebei Yi Ke Da Xue Xue Bao, 2013, 34:388-390.[焦保华, 梁朝辉, 王苑宇, 孙实安, 席增辉. 人脑胶质瘤标本库的初步建立与管理[J]. 河北医科大学学报, 2013, 34:388-390.]
[23] Snyder J, Poisson LM, Noushmehr H, Castro AV, deCarvalho AC, Robin A, Mukherjee A, Lee I, Walbert T. Clinical and research applications of a brain tumor tissue bank in the age of precision medicine[J]. Per Med, 2019, 16:145-156.
[24] Bao AM, Wu JL. The significance and present situation of human brain tissue bank construction in China[J]. Zhen Duan Xue Li Lun Yu Shi Jian, 2018, 17:373-376.[包爱民, 吴娟利. 中国人脑组织库建设的意义及国内外现状[J]. 诊断学理论与实践, 2018, 17:373-376.]
[25] Duan SM, Bao AM. Building a Chinese brain bank to help China's brain science research[J]. Ke Ji Dao Bao, 2019, 37:1.[段树民, 包爱民. 建设中国人脑库,助力中国脑科学研究[J].科技导报, 2019, 37:1.]
[26] Poloni TE, Medici V, Carlos AF, Davin A, Ceretti A, Mangieri M, Cassini P, Vaccaro R, Zaccaria D, Abbondanza S, Bordoni M, Fantini V, Fogato E, Cereda C, Ceroni M, Guaita A. Abbiategrasso brain bank protocol for collecting, processing and characterizing aging brains[J]. J Vis Exp, 2020:e60296.
[27] Lin MP, Jowsey T, Curtis MA. Why people donate their brain to science:a systematic review[J]. Cell Tissue Bank, 2019, 20:447-466.
[28] Xiao LF. Academician Mu Ming Pu:brain science and brain-like intelligence[J]. Gao Ke Ji Yu Chan Ye Hua, 2021, 27:20-23.[肖琳芬. 蒲慕明院士:脑科学与类脑智能[J]. 高科技与产业化, 2021, 27:20-23.]
[29] Qiu WY, Ma C, Bao AM, Zhu KQ, Huang Y, Yan XX, Zhang J, Zhong CJ, Zhou JN, Shen Y, Zheng XY, Zhang LW, Shu YS, Tang BS, Zhang ZX, Duan SM. Standardized operational protocol for human brain banking in China[J]. Jie Pou Xue Bao, 2017, 48:334-341.[仇文颖, 马超, 包爱民, 竺可青, 黄越,严小新, 章京, 钟春玖, 周江宁, 申勇, 郑晓瑛, 张力伟, 舒友生, 唐北沙, 张振馨, 段树民. 中国人脑组织库标准化操作方案[J]. 解剖学报, 2017, 48:334-341.]
[30] Ramirez EPC, Keller CE, Vonsattel JP. The New York Brain Bank of Columbia University:practical highlights of 35 years of experience[J]. Handb Clin Neurol, 2018, 150:105-118.
[31] Shepherd CE, Alvendia H, Halliday GM. Brain banking for research into neurodegenerative disorders and ageing[J]. Neurosci Bull, 2019, 35:283-288.
[32] Schmitt A, Bauer M, Heinsen H, Feiden W, Falkai P, Alafuzoff I, Arzberger T, Al-Sarraj S, Bell JE, Bogdanovic N, Brück W, Budka H, Ferrer I, Giaccone G, Kovacs GG, Meyronet D, Palkovits M, Parchi P, Patsouris E, Ravid R, Reynolds R, Riederer P, Roggendorf W, Schwalber A, Seilhean D, Kretzschmar H; Consortium of Brainnet Europe Ⅱ. How a neuropsychiatric brain bank should be run:a consensus paper of Brainnet EuropeⅡ[J]. J Neural Transm (Vienna), 2007, 114:527-537.
[33] Webster MJ, Kim S. Collecting, storing, and mining research data in a brain bank[J]. Handb Clin Neurol, 2018, 150:167-179.
[34] Labadorf A. The National PTSD Brain Bank:progress, promise, and vision[J]. Psychiatry, 2022, 85:196-200.
[35] Rademaker MC, de Lange GM, Palmen SJMC. The Netherlands brain bank for psychiatry[J]. Handb Clin Neurol, 2018, 150:3-16.
[36] Dufour BD, Albores-Gallo L, Luna-Muñoz J, Hagerman R, Miquelajauregui A, Buriticá E, Saldarriaga W, Pacheco-Herrero M, Yris Silvestre-Sosa A, Mazefsky C, Gastgeb H, Kofler J, Casanova M, Hof PR, London E, Hagerman P, Martínez-Cerdeño V. Hispano:American Brain Bank on neurodevelopmental disorders:an initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders[J]. Brain Pathol, 2022, 32:e13019.
[37] Cao LX, Huang Y, Cai ZY, Chan P, Chen SD, Fan DS, Fang BY, Guo YJ, Han Y, Huang HP, Ji WJ, Li HY, Liu K, Pei Z, Peng DT, Shi FD, Sui Y, Tang BS, Wang F, Wang W, Wang ZX, Wu AH, Xu Y, Yang DD, Zhang GF, Zhang LW, Zhang ZT, Zhao W, Zhao XQ, Wang YJ. Brain bank in neurology history and development[J]. Zhongguo Xian Dai Shen Jing Ji Bing Za Zhi, 2020, 20:914-923.[曹凌晓, 黄越, 蔡志友, 陈彪,陈生弟, 樊东升, 方伯言, 郭燕军, 韩璎, 黄华品, 纪文军, 李红燕, 刘坤, 裴中, 彭丹涛, 施福东, 隋轶, 唐北沙, 王枫, 王雯,王朝霞, 吴安华, 徐运, 杨东东, 张国富, 张力伟, 张振涛, 赵伟, 赵性泉, 王拥军. 脑库与神经病学建设[J]. 中国现代神经疾病杂志, 2020, 20:914-923.]
[38] Azizi L, Garrick TM, Harper CG. Brain donation for research:strong support in Australia[J]. J Clin Neurosci, 2006, 13:449-452.
[39] Dean B, Copolov D, Scarr E. Understanding the pathophysiology of schizophrenia:contributions from the Melbourne Psychiatric Brain Bank[J]. Schizophr Res, 2016, 177:108-114.
[40] Sheedy D, Garrick T, Dedova I, Hunt C, Miller R, Sundqvist N, Harper C. An Australian Brain Bank:a critical investment with a high return[J]. Cell Tissue Bank, 2008, 9:205-216.
[41] Schmitz P. Information technology for brain banking[J]. Handb Clin Neurol, 2018, 150:157-165.
[42] Klioueva NM, Rademaker MC, Huitinga I. Design of a European code of conduct for brain banking[J]. Handb Clin Neurol, 2018, 150:51-81.
[43] Deep-Soboslay A, Benes FM, Haroutunian V, Ellis JK, Kleinman JE, Hyde TM. Psychiatric brain banking:three perspectives on current trends and future directions[J]. Biol Psychiatry, 2011, 69:104-112.
[44] Vonsattel JP, Amaya Mdel P, Cortes EP, Mancevska K, Keller CE. Twenty-first century brain banking:practical prerequisites and lessons from the past:the experience of New York Brain Bank, Taub Institute, Columbia University[J]. Cell Tissue Bank, 2008, 9:247-258.
[45] Grinberg LT, Ferretti RE, Farfel JM, Leite R, Pasqualucci CA, Rosemberg S, Nitrini R, Saldiva PH, Filho WJ; Brazilian Aging Brain Study Group. Brain bank of the Brazilian aging brain study group:a milestone reached and more than 1,600 collected brains[J]. Cell Tissue Bank, 2007, 8:151-162.
[46] de Oliveira KC, Nery FG, Ferreti RE, Lima MC, Cappi C, Machado-Lima A, Polichiso L, Carreira LL, Ávila C, Alho AT, Brentani HP, Miguel EC, Heinsen H, Jacob-Filho W, Pasqualucci CA, Lafer B, Grinberg LT. Brazilian psychiatric brain bank:a new contribution tool to network studies[J]. Cell Tissue Bank, 2012, 13:315-326.
[47] Zhang H, Chen K, Wang N, Zhang D, Yang Q, Zhang Q, Liu P, Wan M, Gong C, Hong X, Qiu W, Qian X, Chen Y, Ma C. Analysis of brain donors' demographic and medical characteristics to facilitate the construction of a human brain bank in China[J]. J Alzheimers Dis, 2018, 66:1245-1254.
[48] Du J, Li S, Fan P, Cui HX. Construction and progress of human brain tissue bank in Hebei Medical University[C/OL]//Department of Human Anatomy, Hebei Medical University. Abstracts of 2019 Annual Meeting of Chinese Anatomical Society. Kunming:Zhongguo Jie Pou Xue Hui, 2019:82[2021-06-25] [杜鹃, 李莎, 樊平, 崔慧先. 河北医科大学人脑组织库建设及进展[C/OL]//河北医科大学人体解剖学教研室. 中国解剖学会2019年年会论文文摘汇编, 昆明:中国解剖学会, 2019:82[2021-06-25].]
[49] Li WS, Wu JS, You LY, Yuan XS, Zhu KM, Fan WK, Xian WW, Zhou GM, Mao Y. Shanghai Brain Bank:current situation and future planning of whole brain bank construction[C/OL]//Department of Anatomy and Tissue embryology, School of Basic Medical Sciences, Fudan University. Abstracts of 2019 Annual Meeting of Chinese Anatomical Society, Kunming:Zhongguo Jie Pou Xue Hui, 2019:82[2021-06-25] [李文生, 吴劲松, 尤琳雅,袁向山, 朱克明, 樊文科, 咸伟伟, 周国民, 毛颖. 上海脑库-全脑库建设现状及未来规划[C/OL]//复旦大学基础医学院解剖与组织胚胎学系. 中国解剖学会2019年年会论文文摘汇编, 昆明:中国解剖学会, 2019:82[2021-06-25].]
[50] Xie WZ, He HY, Deng XT, Luo AJ. Study on social support status and influencing factors of family members of organ donors[J]. Zhonghua Yi Zhi Za Zhi (Dian Zi Ban), 2021, 15:359-364.[谢文照, 贺海燕, 邓渲桐, 罗爱静. 器官捐献者家属社会支持现状及影响因素[J]. 中华移植杂志(电子版), 2021, 15:359-364.]
[51] Zeng WJ, Tang YH, Zhao JQ, Yu XL. Analysis of related factors affecting the willingness of family members of potential organ donors to donate[J]. Hu Shi Jin Xiu Za Zhi, 2021, 36:677-680.[曾维君, 唐义红, 赵加全, 喻行莉. 潜在器官捐献者家属捐献意愿现状及影响因素分析[J]. 护士进修杂志, 2021, 36:677-680.]
[52] Xie Y, Lei L, Xie Q, Duan FJ, Luo Y. The present situation and thinking about the coordination process of organ donation[J]. Hu Li Xue Bao, 2021, 28:40-44.[解雨, 雷蕾, 谢勤, 段方见, 罗羽. 器官捐献中劝捐协调过程的现状与思考[J]. 护理学报, 2021, 28:40-44.]
[53] Zhang S. Human body organ donation:seeking for proper combination of egoism and altruism[J]. Yi Xue Yu Zhe Xue, 2014, 35:5-7.[张珊. 尸体器官捐献:寻求利己与利他的合宜[J]. 医学与哲学, 2014, 35:5-7.]
[54] Zhang Q, Deng J, Li YN, Gou Y, Yan XX, Li F, Pan AH. Perceptions and attitudes toward brain donation among the Chinese people[J]. Anat Sci Educ, 2020, 13:80-90.
[55] Wang HB, Shi Y, Zhou ZY, Fan J. Current status of deceased organ donation and allocation of China[J]. Zhonghua Qi Guan Yi Zhi Za Zhi, 2021, 42:195-196.[王海波, 史赢, 周稚烨, 樊静. 我国死亡器官捐献与分配工作建设的现状[J]. 中华器官移植杂志, 2021, 42:195-196.]
[56] Pan F. Promoting the development of neural network surgery in clinical practice:interview with Professor Zhao Jizong, academician of Chinese Academy of Sciences and Beijing Tiantan Hospital[J]. Zhongguo Yi Yao Dao Bao, 2021, 18:1-3.[潘锋. 在临床实践中推动神经网络外科学发展——访中国科学院院士、北京天坛医院赵继宗教授[J]. 中国医药导报, 2021, 18:1-3.]

选择文件类型/文献管理软件名称

选择包含的内容

2 我国脑肿瘤专病人脑组织资源库建设意义及进展

Significance and progress of the construction of human brain bank for the patients of brain tumors in China

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	佟志勇. 颅内动脉瘤与脑血管重建术[J]. 中国现代神经疾病杂志, 2024, 24(8): 595-598.
[2]	佟志勇. 脑血管重建术历史沿革[J]. 中国现代神经疾病杂志, 2024, 24(8): 599-605.
[3]	金凌骥, 胡俊文, 李寅, 王林. 复杂颅内动脉瘤的颅内-颅内血管搭桥术[J]. 中国现代神经疾病杂志, 2024, 24(8): 606-612.
[4]	刘佩玺, 史源, 朱巍. 血流导向时代颅内全域脑血管搭桥术治疗颅内动脉瘤之应用方略[J]. 中国现代神经疾病杂志, 2024, 24(8): 613-618.
[5]	张峰, 孟凡刚. 帕金森病自主神经功能障碍丘脑底核脑深部电刺激术治疗进展[J]. 中国现代神经疾病杂志, 2024, 24(7): 510-515.
[6]	吴桂智, 田宏. Meige综合征脑深部电刺激术治疗进展[J]. 中国现代神经疾病杂志, 2024, 24(7): 516-521.
[7]	孟凡刚, 张建国. 耳后磨骨槽技术在脑深部电刺激术中的应用[J]. 中国现代神经疾病杂志, 2024, 24(7): 522-524.
[8]	陈琳, 潘华. 功能性震颤的电生理诊断[J]. 中国现代神经疾病杂志, 2024, 24(7): 573-578.
[9]	魏俊吉, 常健博. 深入基层医院普及神经外科重症管理理念[J]. 中国现代神经疾病杂志, 2024, 24(6): 403-406.
[10]	史若琳, 高秀洁, 崔家宁, 邵妍, 谢璐霜, 刘毅. 5-羟色胺与帕金森病非运动症状研究进展[J]. 中国现代神经疾病杂志, 2024, 24(6): 497-501.
[11]	李海峰. 在进入靶向治疗的时代激素仍然是重症肌无力治疗的基础[J]. 中国现代神经疾病杂志, 2024, 24(5): 295-307.
[12]	许鸿嘉, 舒崖清, 王蘋, 李蕃, 许顺良, 邱伟, 马晓宇. 抗水通道蛋白4抗体阳性视神经脊髓炎谱系疾病诊断与治疗进展[J]. 中国现代神经疾病杂志, 2024, 24(5): 308-314.
[13]	黄瑀, 廖金池, 舒崖清. 抗N-甲基-D-天冬氨酸受体脑炎睡眠障碍研究进展[J]. 中国现代神经疾病杂志, 2024, 24(5): 315-319.
[14]	刘彩云, 金涛. 树突状细胞在多发性硬化免疫治疗中的应用[J]. 中国现代神经疾病杂志, 2024, 24(5): 320-330.
[15]	王军成, 赵岳阳, 杨强, 蒯涛, 潘亚文. HMGB1基因调控胶质瘤恶性生物学行为研究进展[J]. 中国现代神经疾病杂志, 2024, 24(5): 391-397.

模态框（Modal）标题

选择文件类型/文献管理软件名称

选择包含的内容

2 我国脑肿瘤专病人脑组织资源库建设意义及进展

Significance and progress of the construction of human brain bank for the patients of brain tumors in China

RichHTML

PDF

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价