摘要：

目的 总结氩氦刀冷冻消融术辅助颅内肿瘤切除术的疗效。 方法与结果 共11 例原发性颅内肿瘤患者（包括7 例胶质瘤和4 例脑膜瘤），肿瘤分别位于左侧额叶4 例、左侧额顶叶2 例、左侧颞叶2 例、右侧颞顶叶3 例，均采用氩氦刀冷冻消融术辅助颅内肿瘤切除术。7 例胶质瘤全切除4 例、部分切除3 例，4 例脑膜瘤均全切除；平均术中出血量80 ml，平均手术时间80 min；术后临床症状改善；复查头部CT 或MRI 未发生再出血；术后平均随访4 年，无一例发生颅内感染等手术相关或术后并发症，未见肿瘤复发。 结论 氩氦刀冷冻消融术适用于不同部位和不同直径的颅内肿瘤，安全有效、手术相关和术后并发症较少、再出血和肿瘤复发风险较低，是一种安全、有效、经济的辅助手术方法。

关键词: 中枢神经系统肿瘤, 氩, 氦, 冷冻外科手术, 神经外科手术

Abstract:

Objective  To summarize the curative effect of argon-helium cryoablation in resection of intracranial tumors.  Methods and Results  A total of 11 patients with primary intracranial tumors, including 7 cases of glioma and 4 cases of meningioma, were enrolled in this study. The tumor was located in left frontal lobe in 4 cases, left fronto-parietal lobe in 2 cases, left temporal lobe in 2 cases and right temporo-parietal lobe in 3 cases. Argon-helium cryoablation was used to assist intracranial tumor resection. Among 7 cases of glioma, 4 cases were totally removed and 3 cases were partially resected. Four cases of meningioma were totally removed. The average intraoperative blood loss was 80 ml, and average operation time was 80 min. Postoperative clinical symptoms were improved, and head CT or MRI showed no rebleeding. Patients were followed up for an average of 4 years, and none of them suffered from operation-related or postoperative complications such as intracranial infection, or tumor recurrence.  Conclusions  Argon - helium cryoablation is suitable for intracranial tumors with different diameters and in different locations. It is safe and effective, with few operation-related or postoperative complications, less rebleeding and low risk of recurrence, which is a highly efficient and relatively low?cost assistant surgical method.

Key words: Central nervous system neoplasms, Argon, Helium, Cryosurgery, Neurosurgical procedures