摘要：

目的 筛查缺血性脑血管病合并不宁腿综合征的相关危险因素。方法 共370 例首次发作的缺血性脑血管病患者根据是否合并不宁腿综合征，分为缺血性脑血管病合并不宁腿综合征组（不宁腿综合征组，45 例）和不合并不宁腿综合征组（无不宁腿综合征组，325 例），详细记录性别、年龄、体重指数、受教育程度、民族、职业、生活方式、体育锻炼、既往史、女性孕产史和绝经年龄；血液化学检测白细胞计数、血红蛋白、血清肌酐、尿素氮、空腹血糖、血清脂质、血浆同型半胱氨酸、血清铁等。结果 不宁腿综合征组体重指数高于无不宁腿综合征组（t = 2.457，P = 0.014），血红蛋白（t = 2.819，P = 0.005）和血清铁（t = 2.168，P = 0.024）低于无不宁腿综合征组。多因素前进法Logistic 回归分析显示，血红蛋白降低（OR = 1.049，95%CI：1.017 ~ 1.082；P = 0.002）和血清铁降低（OR = 1.121，95%CI：1.002 ~ 1.254；P = 0.047）是缺血性脑血管病合并不宁腿综合征的独立危险因素。结论 缺血性脑血管病合并不宁腿综合征临床较为常见，此类患者血红蛋白和血清铁水平较低。

关键词: 脑血管障碍, 脑缺血, 不宁腿综合征, 危险因素, 回归分析

Abstract:

Objective  To explore the risk factors for restless legs syndromes (RLS) in patients with ischemic cerebrovascular disease (ICVD).  Methods  There were 370 patients with ICVD, 45 cases were combined with RLS (RLS group) and 325 cases were not combined with RLS (non-RLS group). The general clinical data [sex, age, body mass index (BMI), education, nationality, occupation, lifestyle, physical exercise, medical history, history of gestation and age of menopause in female] were recorded, and related chemical examinations [white cell count (WBC), hemoglobin (Hb), serum creatinine (Cr), blood urea nitrogen (BUN), fasting blood glucose, serum lipid, plasma homocysteine (Hcy), serum iron] were performed.  Results  Compared with non-RLS group, BMI of patients in RLS group was higher (t = 2.457, P = 0.014), Hb (t = 2.819, P = 0.005) and serum iron (t = 2.168, P = 0.024) were lower. Multivariate forward Logistic regression analysis showed that low Hb (OR = 1.049, 95%CI: 1.017-1.082; P = 0.002) and serum iron (OR = 1.121, 95% CI: 1.002-1.254; P = 0.047) were the risk factors for ICVD combined with RLS patients.  Conclusions  RLS is common among patients with ICVD, and they have low Hb and serum iron levels.

Key words: Cerebrovascular disorders, Brain ischemia, Restless legs syndrome, Risk factors, Regression analysis