摘要:
淀粉样脑血管病相关性中枢神经系统血管炎亦称为β-淀粉样蛋白(Aβ)相关性中枢神经系统血管炎,主要表现为存在Aβ沉积的小血管壁或其周围慢性炎症性变。考虑部分患者临床表现、脑脊液和影像学表现不典型,明确诊断仍需依靠脑组织活检。本文拟就其发病机制、病理学特征、临床表现、治疗及预后等进展进行概述。
关键词:
淀粉样β蛋白,
血管炎, 中枢神经系统,
病理学,
综述
Abstract:
Amyloid β (Aβ)-related central nervous system (CNS) vasculitis, which is also known as cerebral amyloid angiopathy (CAA)-related CNS vasculitis, is characterized by the presence of chronic inflammation within or around the walls of Aβ-deposit blood vessels. Cerebral biopsy is the gold standard for diagnosis of A β-related CNS vasculitis considering the atypical clinical features, cerebrospinal fluid (CSF) and neuroimaging findings of some patients. This paper reviewed the pathogenesis, neuropathology, clinical features, treatment and prognosis of Aβ-related CNS vasculitis
Key words:
Amyloid beta-protein,
Vasculitis, central nervous system,
Pathology,
Review
李卓, 朴月善, 卢德宏. β-淀粉样蛋白相关性中枢神经系统血管炎[J]. 中国现代神经疾病杂志, 2016, 16(1): 3-7.
LI Zhuo, PIAO Yue-shan, LU De-hong. Amyloid β-related central nervous system vasculitis[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2016, 16(1): 3-7.