中国现代神经疾病杂志 ›› 2014, Vol. 14 ›› Issue (9): 769-774. doi: 10.3969/j.issn.1672-6731.2014.09.006

• 专题讲座 • 上一篇    下一篇

2 神经精神狼疮自身免疫发病机制

谢长好, 廖翔, 孙凌云, 邓国民   

  1. 210029 南京医科大学基础医学院微生物学与免疫学系(谢长好,廖翔,邓国民);210008 南京医科大学附属鼓楼临床学院风湿免疫科(孙凌云)
  • 出版日期:2014-09-25 发布日期:2014-09-24
  • 通讯作者: 邓国民 (Email:gmdeng@njmu.edu.cn);孙凌云 (Email:lingyunsun2012@163.com)
  • 基金资助:

    南京医科大学引进人才启动基金资助项目(项目编号:KY101RC071203)

Autoimmune pathogenesis of neuropsychiatric systemic lupus erythematosus

XIE Chang-hao1, LIAO Xiang1, SUN Ling-yun2, DENG Guo-min1   

  1. 1Department of Microbiology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, Jiangsu, China
    2Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu, China
  • Online:2014-09-25 Published:2014-09-24
  • Contact: DENG Guo-min (Email: gmdeng@njmu.edu.cn); SUN Ling-yun (Email: lingyunsun2012@163.com)
  • Supported by:

    This study was supported by Fund of Nanjing Medical University (No. KY101RC071203).

摘要: 系统性红斑狼疮是慢性自身免疫性疾病,主要特征为多种自身抗体产生和多系统损害,累及中枢和外周神经系统时称神经精神狼疮。神经精神狼疮是系统性红斑狼疮患者死亡的主要原因之一,发病机制复杂,目前认为主要有两种机制参与其发病,一是自身抗体和免疫复合物介导的脑血管损害;二是自身免疫反应产生的炎性因子引起的脑组织损害。

关键词: 狼疮血管炎, 中枢神经系统, 自身抗体, 综述

Abstract: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease, which is characterized by high levels of autoantibodies and multisystem damage. Neuropsychiatric SLE (NPSLE) involves both the central and peripheral nervous systems, which is one major cause of death in SLE patients. Pathogenesis of NPSLE is complicated. Currently it is known that there are two mechanisms to be involved in NPSLE: one is cerebrovascular injury mediated by immune complex containing autoantibodies, and the other is brain tissue damage induced by inflammatory mediators originated from autoimmunity.

Key words: Lupus vasculitis, central nervous system, Autoantibodies, Review