中国现代神经疾病杂志 ›› 2014, Vol. 14 ›› Issue (8): 717-721. doi: 10.3969/j.issn.1672-6731.2014.08.013

• 临床研究 • 上一篇    下一篇

2 缺血性卒中急性期他汀类药物治疗对血清超敏C-反应蛋白影响及预后评价

毕欣伟, 陈立云   

  1. 100038 首都医科大学附属北京世纪坛医院神经与精神病科
  • 出版日期:2014-08-25 发布日期:2014-08-06
  • 通讯作者: 陈立云(Email:chenleeyun@263.net)

The effect of statin therapy for acute ischemic stroke on high-sensitivity C-reactive protein and the prognosis

BI Xin-wei, CHEN Li-yun   

  1. Department of Neurology and Psychiatry, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
  • Online:2014-08-25 Published:2014-08-06
  • Contact: CHEN Li-yun (Email: chenleeyun@263.net)

摘要: 对他汀类药物治疗组(他汀治疗组)或非他汀类药物治疗组(对照组)患者入院时和发病30 d 时临床资料进行分析,并比较两组血清超敏C-反应蛋白水平的变化。结果显示,他汀治疗组患者发病30 d 时血清超敏C-反应蛋白低于对照组(t = 9.925,P = 0.015),发病后3 个月预后优于对照组(χ2 =4.762,P = 0.029);经逐步Logistic 回归分析,入院时美国国立卫生研究院卒中量表评分(OR = 1.383,95%CI:1.062 ~ 1.800;P = 0.028)和发病48 h 血清超敏C-反应蛋白水平(OR = 1.472,95%CI:0.500 ~ 4.370;P =0.001)对患者发病3 个月时的预后具有独立预测作用。提示他汀类药物可以降低急性缺血性卒中患者血清超敏C-反应蛋白水平,对发病3 个月时的预后具有预测作用。

关键词: 卒中, C 反应蛋白质, 降血脂药, 预后

Abstract: The clinical data of 100 patients with acute ischemic stroke on admission and 30 d after stroke were analyzed. The patients were evenly divided into 2 groups (statin group and control group). Serum high-sensitivity C-reactive protein (hs-CRP) level was similar in the 2 groups within 48 h after onset, but was significantly lower in statin group 30 d after onset (t = 9.925, P = 0.015). The statin group also had better 3-month outcome ( χ2 = 4.762, P = 0.029). After using stepwise Logistic regression analysis, only National Institute of Health Stroke Scale (NIHSS) score on admission (OR = 1.383, 95%CI: 1.062-1.800; P = 0.028) and hs-CRP in the acute phase (OR = 1.472, 95%CI: 0.500-4.370; P = 0.001) were significantly and independently predictive for 3-month outcome. This study indicates that statin therapy reduces hs-CRP level in the acute phase and can predict the 3-month clinical outcome of ischemic stroke.

Key words: Stroke, C-reactive protein, Antilipemic agents, Prognosis