中国现代神经疾病杂志 ›› 2014, Vol. 14 ›› Issue (11): 1019-1022. doi: 10.3969/j.issn.1672-6731.2014.11.018

• 临床研究 • 上一篇    下一篇

2 糖尿病与急性缺血性卒中静脉溶栓预后的相关性分析

张春阳, 张会岭, 石秋艳, 李艳玲, 马晨   

  1. 063000 唐山,河北联合大学附属医院神经重症病房(张春阳,石秋艳,李艳玲);064400 河北省迁安市中医院眼科(张会岭);300450 天津市第五中心医院神经内科(马晨)
  • 出版日期:2014-11-25 发布日期:2014-11-29
  • 通讯作者: 张春阳 (Email:zcycycy1979@163.com)
  • 基金资助:

    河北省唐山市科技计划项目(项目编号:13130206a)

Analysis of correlation between diabetes and prognosis in thrombolytic patients with acute ischemic stroke

ZHANG Chun-yang1, ZHANG Hui-ling2, SHI Qiu-yan1, LI Yan-ling1, MA Chen3   

  1. 1Neurological Intensive Care Unit, Hebei United University Affiliated Hospital, Tangshan 063000, Hebei, China
    2Department of Ophthalmology, Qian'an Hospital of Traditional Chinese Medicine, Qian'an 064400, Hebei, China
    3Department of Neurology, Tianjin Fifth Central Hospital, Tianjin 300450, China
  • Online:2014-11-25 Published:2014-11-29
  • Contact: ZHANG Chun-yang (Email: zcycycy1979@163.com)
  • Supported by:

    This study was supported by Tangshan Science and Technology Plan Project of Hebei Province (No. 13130206a).

摘要: 根据是否合并糖尿病将153 例急性缺血性卒中患者分为糖尿病组和非糖尿病组,观察两组患者一般特征和预后,多因素逐步法Logistic 回归分析评价糖尿病与静脉溶栓预后关联性。结果显示,糖尿病组患者溶栓治疗后90 d 获得良好预后比例低于非糖尿病组(26.83%对41.96%;χ2 = 11.692,P = 0.001);Logistic 回归分析提示糖尿病与缺血性卒中预后不良存在关联性(OR = 1.224,95%CI:1.034 ~ 1.449;P = 0.019)。糖尿病与急性缺血性卒中静脉溶栓治疗患者预后不良呈高度相关。

关键词: 糖尿病, 脑缺血, 组织型纤溶酶原激活物, 回归分析

Abstract: A total of 153 patients with acute ischemic stroke were divided into diabetes group and non-diabetes group. Baseline characteristics and prognosis were observed and compared between patients of the 2 groups. The correlation between diabetes and outcome after intravenous thrombolysis was analyzed by multivariate stepwise Logistic regression analysis. The results showed that the patients in diabetes group accounted for less favorable outcome than that in non-diabetes group (26.83% vs 41.96%; χ2 = 11.692, P = 0.001) at 90 d after thrombolytic treatment. Logistic regression analysis indicated that diabetes was relevant to unfavorable outcome of ischemic stroke (OR = 1.224, 95% CI: 1.034-1.449; P = 0.019). The results illustrate that diabetes is highly relevant to unfavorable outcome of thrombolytic patients with acute ischemic stroke.

Key words: Diabetes mellitus, Brain ischemia, Tissue plasminogen activator, Regression analysis