中国现代神经疾病杂志 ›› 2014, Vol. 14 ›› Issue (10): 910-914. doi: 10.3969/j.issn.1672-6731.2014.10.016

• 综述 • 上一篇    下一篇

2 氧化应激与脑血管病危险因素

盛冲霄, 黎红华   

  1. 430070 广州军区武汉总医院神经内科
  • 出版日期:2014-10-25 发布日期:2014-10-14
  • 通讯作者: 黎红华(Email:Lihonghua567@yahoo.com)
  • 基金资助:

    湖北省自然科学基金资助项目( 项目编号:2013CFB428)

Oxidative stress and risk factors for cerebrovascular diseases

SHENG Chong-xiao, LI Hong-hua   

  1. Department of Neurology, Wuhan General Hospital of Guangzhou Military Command of Chinese PLA, Wuhan 430070, Hubei, China
  • Online:2014-10-25 Published:2014-10-14
  • Contact: LI Hong-hua (Email: Lihonghua567@yahoo.com)
  • Supported by:

    This study was supported by Natural Science Foundation of Hubei Province (No. 2013CFB428).

摘要: 氧化应激系指机体活性氧产生过多和(或)机体抗氧化能力减弱,产生与清除失衡,导致活性氧在体内聚积并引起细胞氧化损伤的病理过程。这一病理过程与脑血管病关系密切,吸烟、血糖水平波动、高脂血症、高血压和高同型半胱氨酸血症等多种脑血管病危险因素均可使活性氧的产生增加。

关键词: 卒中, 活性氧, 氧化性应激, 危险因素, 综述

Abstract: Oxidative stress refers to the pathological process of cell oxidative damage that caused by increased reactive oxygen species (ROS) aggregation in vivo, due to the excessive generation of ROS and/or decreased anti-oxidant ability, resulting in imbalance between ROS producing and scavenging mechanism. Oxidative stress, which is closely related with cerebrovascular diseases, is involved in the pathological process of many diseases. Several cerebrovascular disease risk factors, such as smoking, blood glucose fluctuation, hyperlipemia, hypertension and hyperhomocysteinemia, can cause the increasing of ROS.

Key words: Stroke, Reactive oxygen species, Oxidative stress, Risk factors, Review