摘要: 检测偏头痛患者血脂和内皮素-1 表达水平,观察二者之间相关性。结果显示,偏头痛组患者,尤其是伴血脂异常者血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇及内皮素-1 水平均高于正常对照组(P < 0.05);偏头痛组患者血清内皮素-1 与总胆固醇(rs = 0.208,P = 0.043)、甘油三酯(rs = 0.331,P =0.001)、低密度脂蛋白胆固醇(rs = 0.217,P = 0.035)呈正相关关系,而与高密度脂蛋白胆固醇无关联性(rs = -0.099,P = 0.341)。提示血脂及内皮素-1 在偏头痛发作过程中起重要作用,了解血脂与内皮素-1 之间的相关关系,有效控制血脂水平,对预防偏头痛具有重要意义。
关键词:
偏头痛,
内皮缩血管肽类,
高脂血症
Abstract: Objective To detect the levels of serum lipid and endothelin-1 (ET-1) in acute period migraine, and to observe the correlation between them. Methods The serum lipid level in healthy control group (N = 42) and migraine group (N = 95) was detected by automatic biochemical detector and serum ET-1 level of two groups was measured by radioimmunoassay method. Results Compared with healthy control group, the levels of total cholesterol (TC), trighyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ET-1 in migraine group, especially patients with dyslipidemia, were significantly higher (P < 0.05, for all), while the difference of high?density lipoprotein cholesterol (HDL-C) level had no statistical significance (P > 0.05). Serum ET-1 content in migraine group was positively correlated with the levels of TC (rs = 0.208, P = 0.043), TG (rs = 0.331, P = 0.001), LDL-C (rs = 0.217, P = 0.035), but was not correlated with HDL-C level (rs = -0.099, P = 0.341). Conclusion The changes of serum lipid and ET-1 level play an important role in the process of migraine attacks. Serum ET-1 has positive correlation with TG, TC, LDL-C levels, suggesting the correlation of serum lipid and ET-1 in acute period migraineurs and effective control for serum lipid has important significance for the prevention of migraine and cardiovascular diseases.
Key words:
Migraine disorders,
Endothelins,
Hyperlipidemias
张中菊, 杨丽. 偏头痛患者内皮素-1与血脂异常的相关性研究[J]. 中国现代神经疾病杂志, 2013, 13(9): 783-786.
ZHANG Zhong-ju, YANG Li. The correlation of endothelin-1 and dyslipidemia in migraineurs[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2013, 13(9): 783-786.