摘要： 生物日节律是地球生物受昼夜更替影响的普遍现象，是生命活动的基本组成，几乎涉及机体所有组织与器官的生理活动。这种全身协调的动态变化是多种机制的共同参与和信息整合。在所有参与睡眠-觉醒动态循环调控的环节中，受体至关重要，为细胞内信号效应的启动点，同时亦是重要的干预靶点。对目前已知参与睡眠-觉醒循环调节受体的种类进行归纳，并对其功能研究进展进行阐述，有助于进一步了解睡眠-觉醒的生理过程，亦为干预其病理生理变化的研究提供有效信息。

关键词: 睡眠, 觉醒, 昼夜节律, 受体, 褪黑激素, 受体, 神经肽, 激素类, 受体, 神经递质, 综述

Abstract: Circadian rhythm is a universal phenomenon driven by the day-night cycle among the living beings on the earth. It is considered a basic element of life, which involves oscillations of most physiological activity through the body. The coordination of the different physiologic activities should be attributed to the convergence of a diversity of regulatory mechanisms. Among the multiple links in sleep-wake cycle, the receptors are of primary importance. Since they initiate the downstream signaling leading to cell responses, the receptors are considered a commonly intervention target. Here we summarize the major
receptors in sleep-wake regulation, along with a brief introduction of their functional findings, aiming to provide clues to further function understanding and intervention developing.

Key words: Sleep, Arousal, Circadian rhythm, Receptors, melatonin, Receptors, neuropeptide, Hormones, Receptors, neurotransmitter, Review