摘要：

随着人口老龄化的加剧，阿尔茨海默病给全球公共卫生系统带来沉重负担。近年阿尔茨海默病发病机制、诊断方法、疾病修饰治疗等方面取得重大进展，同时对临床提出新的方向和挑战，亟待制定符合当前临床诊断与治疗的标准化方案。通过深度检索阿尔茨海默病相关文献，包括Meta分析和系统综述、随机对照试验、队列研究等，采用改编版证据质量和推荐分级的评估、制定与评价方法对推荐等级和证据级别进行分级，撰写《阿尔茨海默病诊断规范共识》，整合神经心理评估、神经影像学、生物学标志物等多模态技术的应用要点，兼顾临床实用性与前沿研究证据，为阿尔茨海默病的规范化诊断提出工作框架和专家推荐建议。

关键词: 阿尔茨海默病, 诊疗指南, 心理学试验, 血浆, 脑脊髓液, 淀粉样β肽类, tau蛋白质类, 正电子发射断层显像术, 脑电描记术, 基因检测

Abstract:

With the escalating global aging population, Alzheimer's disease (AD) has imposed social and economic burden on public health systems worldwide. In recent years, significant advancements have been achieved in understanding the pathogenesis, diagnostic methods, and disease-modifying therapy (DMT), which simultaneously present new directions and challenges for clinical practice. Therefore, there is an urgent need to develop standardized protocols aligned with current clinical diagnosis and treatment requirements. By comprehensively searching Alzheimer's disease-related literatures, including Meta-analyses, systematic reviews, randomized controlled trials, and cohort studies, we adopted modified Grades of Recommendations Assessment Development and Evaluation (GRADE) system to grade the quality of evidence and strength of recommendations, the "Consensus on diagnostic criteria for Alzheimer's disease" has been compiled, integrating key application points of integrating multimodal techniques such as neuropsychological assessment, neuroimaging and biomarkers, while balancing clinical applicability with cutting-edge evidence, to propose a practical framework and expert recommendations for the standardized diagnosis of Alzheimer's disease.

Key words: Alzheimer disease, Diagnostic and treatment guideline, Psychological tests, Plasma, Cerebrospinal fluid, Amyloid beta-peptides, Tau proteins, Positron-emission tomography, Electroencephalography, Genetic testing

中图分类号: 

• R741