癫痫相关小胶质细胞分子信号转导机制研究进展

doi:10.3969/j.issn.1672-6731.2023.10.013

摘要/Abstract

摘要：

小胶质细胞在癫痫发生发展中具有重要作用，表现为激活的小胶质细胞可以释放炎性因子，介导神经细胞吞噬与凋亡，促进癫痫的反复、持续发作。本文对癫痫相关小胶质细胞介导的信号转导通路进行综述，梳理小胶质细胞分子信号转导机制在癫痫发生发展中的作用。

Abstract:

Existing studies have proved that microglia plays an important role in the occurrence and development of epilepsy, which shows that activated microglia can release inflammatory factors, mediate cell phagocytosis and apoptosis, and affect the activity and number of neurons, so as to promote recurrent and persistent seizures. This article reviews the signal pathways mediated by microglia related to epilepsy and sort out the role of microglia molecular mechanism in the occurrence and development of epilepsy.

Key words: Epilepsy, Microglia, Inflammation, Autophagy, Apoptosis, Review

贾音, 曾常茜, 王丹. 癫痫相关小胶质细胞分子信号转导机制研究进展[J]. 中国现代神经疾病杂志, 2023, 23(10): 948-953.

Yin JIA, Chang-qian ZENG, Dan WANG. Research progress on molecular signal transduction mechanism of epilepsy - related microglia[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2023, 23(10): 948-953.

https://journal11.magtechjournal.com/cjcnn/CN/Y2023/V23/I10/948

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