中国现代神经疾病杂志 ›› 2023, Vol. 23 ›› Issue (10): 884-888. doi: 10.3969/j.issn.1672-6731.2023.10.003

• 专题综述 • 上一篇    下一篇

2 颅脑创伤脑脊液标志物研究进展

刘俊, 张国斌*()   

  1. 300350 天津市环湖医院颅脑创伤与重症医学科
  • 收稿日期:2023-09-29 出版日期:2023-10-25 发布日期:2023-10-31
  • 通讯作者: 张国斌
  • 基金资助:
    天津市卫生健康科技项目(TJWJ2022QN065); 天津市津南区科技计划项目(20220104)

Research progress on cerebrospinal fluid markers in traumatic brain injury

Jun LIU, Guo-bin ZHANG*()   

  1. Department of Traumatic Brain Injury and Intensive Care Unit, Tianjin Huanhu Hospital, Tianjin 300350, China
  • Received:2023-09-29 Online:2023-10-25 Published:2023-10-31
  • Contact: Guo-bin ZHANG
  • Supported by:
    Tianjin Health Science and Technology Project(TJWJ2022QN065); Science and Technology Plan Project in Jinnan District of Tianjin(20220104)

摘要:

颅脑创伤病理生理学机制复杂,脑脊液标志物表达变化可反映脑组织微环境改变且不易受其他因素的干扰,较血清学指标的稳定性和可靠性更高。本文综述颅脑创伤主要脑脊液标志物研究进展,以提高临床对颅脑创伤发病机制的认知,实现颅脑创伤的精准治疗。

关键词: 脑损伤, 创伤性, 生物标记, 综述

Abstract:

The pathophysiological mechanism of traumatic brain injury (TBI) is complex, and the changes of cerebrospinal fluid markers can reflect the changes of brain microenvironment and neurometabolic processes, and are not easily interfered by peripheral factors. Compared with blood markers, they are more stable and reliable. This article reviews the research progress of main cerebrospinal fluid markers in TBI, in order to improve the understanding of the pathogenesis of TBI and achieve precise treatment of TBI.

Key words: Brain injuries, traumatic, Biomarkers, Review