ACE2-Ang-（1-7）-MasR轴与中枢神经系统疾病关系研究进展

doi:10.3969/j.issn.1672-6731.2022.08.014

中国现代神经疾病杂志 ›› 2022, Vol. 22 ›› Issue (8): 738-741. doi: 10.3969/j.issn.1672-6731.2022.08.014

2 ACE2-Ang-（1-7）-MasR轴与中枢神经系统疾病关系研究进展

梁贺¹, 蔺建文¹, 莫名¹, 谢露霜², 杜世伟³, 刘毅¹

1 116033 辽宁省大连市中心医院神经内科;
2 610075 成都中医药大学基础医学院;
3 518111 深圳大学附属华南医院神经外科

收稿日期:2022-07-29 发布日期:2022-09-06
通讯作者: 刘毅,Email:letaliu@bjmu.edu.cn E-mail:letaliu@bjmu.edu.cn
基金资助:
辽宁省兴辽英才计划项目(项目编号:XLYC1807083);辽宁省大连市科技创新基金资助项目(项目编号:2021JJ13SN64)

Research progress on the relationship between ACE2 - Ang - (1 - 7) - MasR axis and central nervous system diseases

LIANG He¹, LIN Jian-wen¹, MO Ming¹, XIE Lu-shuang², DU Shi-wei³, LIU Yi¹

1 Department of Neurology, Dalian Municipal Central Hospital, Dalian 116033, Liaoning, China;
2 School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China;
3 Department of Neurosurgery, South China Hospital of Shenzhen University, Shenzhen 518111, Guangdong, China

Received:2022-07-29 Published:2022-09-06
Supported by:
This study was supported by Liaoning Revitalization Talents Program (No. XLYC1807083), and Dalian Science Innovation Project of Liaoning Province (No. 2021JJ13SN64).

摘要/Abstract

摘要： 肾素-血管紧张素系统（RAS）具有维持心血管稳态、水电解质平衡的作用，这一过程中血管紧张素转化酶Ⅱ（ACE2）及其作用轴血管紧张素1-7 ［Ang- （1-7）］和Mas受体（MasR）共同组成的ACE2-Ang-（1-7）-MasR轴广泛参与中枢神经系统疾病的病理生理学过程。本文总结RAS结构与功能以及ACE2-Ang-（1-7） -MasR轴在缺血性卒中、认知功能障碍、焦虑状态、神经系统变性疾病发病机制中的作用进展，以期提高研究人员和临床医师对ACE2-Ang- （1-7） -MasR轴的认识，为药物研发提供新靶点。

关键词: 中枢神经系统疾病, 肾素-血管紧张素系统, 肽基二肽酶A, 综述

Abstract: Renin - angiotensin system (RAS) plays an important role in maintaining cardiovascular homeostasis, water and electrolyte balance in the body, and angiotensin converting enzyme Ⅱ (ACE2) and its axis of action angiotensin-(1-7) [Ang-(1-7)] and Mas receptor (MasR) composed of Ang-(1-7) and MasR axis can play an important role in this process, it can widely participate in the pathophysiological process of central nervous system diseases. Based on the structure and function of RAS, this study plans to sort out the latest relevant research results on the role of ACE2-Ang-(1-7)-MasR axis in ischemic stroke, cognitive dysfunction, anxiety state and neurodegenerative disease, improve the understanding of researchers and clinicians, and provide ideas for the development of new targets for central nervous system disease drugs in the future.

Key words: Central nervous system diseases, Renin - angiotensin system, Peptidyl - dipeptidase A, Review

梁贺, 蔺建文, 莫名, 谢露霜, 杜世伟, 刘毅. ACE2-Ang-（1-7）-MasR轴与中枢神经系统疾病关系研究进展[J]. 中国现代神经疾病杂志, 2022, 22(8): 738-741.

LIANG He, LIN Jian-wen, MO Ming, XIE Lu-shuang, DU Shi-wei, LIU Yi. Research progress on the relationship between ACE2 - Ang - (1 - 7) - MasR axis and central nervous system diseases[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(8): 738-741.

https://journal11.magtechjournal.com/cjcnn/CN/Y2022/V22/I8/738

参考文献

[1] Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor[J]. Cell, 2020, 181:271-280.e8.
[2] Gironacci MM, Vicario A, Cerezo G, Silva MG. The depressor axis of the renin-angiotensin system and brain disorders:a translational approach[J]. Clin Sci (Lond), 2018, 132:1021-1038.
[3] Alenina N, Bader M. ACE2 in brain physiology and pathophysiology:evidence from transgenic animal models[J]. Neurochem Res, 2019, 44:1323-1329.
[4] Ivan CS, Seshadri S, Beiser A, Au R, Kase CS, Kelly-Hayes M, Wolf PA. Dementia after stroke:the Framingham Study[J]. Stroke, 2004, 35:1264-1268.
[5] Saavedra JM. Beneficial effects of Angiotensin Ⅱ receptor blockers in brain disorders[J]. Pharmacol Res, 2017, 125(Pt A):91-103.
[6] Wright JW, Harding JW. The brain renin-angiotensin system:a diversity of functions and implications for CNS diseases[J]. Pflugers Arch, 2013, 465:133-151.
[7] Hussain M, Awan FR. Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease[J]. Clin Exp Hypertens, 2018, 40:344-352.
[8] Andone S, Bajko Z, Motataianu A, Maier S, Barcutean L, Balasa R. Neuroprotection in stroke-focus on the renin-angiotensin system:a systematic review[J]. Int J Mol Sci, 2022, 23:3876.
[9] Bennion DM, Jones CH, Donnangelo LL, Graham JT, Isenberg JD, Dang AN, Rodriguez V, Sinisterra RDM, Sousa FB, Santos RAS, Sumners C. Neuroprotection by post-stroke administration of an oral formulation of angiotensin-(1-7) in ischaemic stroke[J]. Exp Physiol, 2018, 103:916-923.
[10] Nys GM, van Zandvoort MJ, de Kort PL, Jansen BP, Kappelle LJ, de Haan EH. Restrictions of the mini-mental state examination in acute stroke[J]. Arch Clin Neuropsychol, 2005, 20:623-629.
[11] Sun XY, Li LJ, Dong QX, Zhu J, Huang YR, Hou SJ, Yu XL, Liu RT. Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer's disease[J]. J Neuroinflammation, 2021, 18:131.
[12] Fouda AY, Fagan SC, Ergul A. Brain vasculature and cognition[J]. Arterioscler Thromb Vasc Biol, 2019, 39:593-602.
[13] Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension[J]. Circ Res, 2010, 106:373-382.
[14] Weng S, Lai QL, Wang J, Zhuang L, Cheng L, Mo Y, Liu L, Zhao Z, Zhang Y, Qiao S. The role of exosomes as mediators of neuroinflammation in the pathogenesis and treatment of Alzheimer's disease[J]. Front Aging Neurosci, 2022, 14: 899944.
[15] Kehoe PG, Miners S, Love S. Angiotensins in Alzheimer's disease:friend or foe[J]? Trends Neurosci, 2009, 32:619-628.
[16] Evans CE, Miners JS, Piva G, Willis CL, Heard DM, Kidd EJ, Good MA, Kehoe PG. ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease[J]. Acta Neuropathol, 2020, 139:485-502.
[17] Liu S, Ando F, Fujita Y, Liu J, Maeda T, Shen X, Kikuchi K, Matsumoto A, Yokomori M, Tanabe-Fujimura C, Shimokata H, Michikawa M, Komano H, Zou K. A clinical dose of angiotensin- converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice[J]. J Biol Chem, 2019, 294:9760-9770.
[18] Kamel AS, Abdelkader NF, Abd El-Rahman SS, Emara M, Zaki HF, Khattab MM. Stimulation of ACE2/ANG(1-7)/Mas axis by diminazene ameliorates Alzheimer's disease in the D-galactose-ovariectomized rat model:role of PI3K/Akt pathway[J]. Mol Neurobiol, 2018, 55:8188-8202.
[19] Bali A, Jaggi AS. Angiotensin as stress mediator:role of its receptor and interrelationships among other stress mediators and receptors[J]. Pharmacol Res, 2013, 76:49-57.
[20] Costa-Ferreira W, Morais-Silva G, Gomes-de-Souza L, Marin MT, Crestani CC. The AT1 receptor antagonist losartan does not affect depressive-like state and memory impairment evoked by chronic stressors in rats[J]. Front Pharmacol, 2019, 10:705.
[21] Wang L, de Kloet AD, Pati D, Hiller H, Smith JA, Pioquinto DJ, Ludin JA, Oh SP, Katovich MJ, Frazier CJ, Raizada MK, Krause EG. Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors[J]. Neuropharmacology, 2016, 105:114-123.
[22] Kangussu LM, Almeida-Santos AF, Moreira FA, Fontes MAP, Santos RAS, Aguiar DC, Campagnole-Santos MJ. Reduced anxiety-like behavior in transgenic rats with chronically overproduction of angiotensin-(1-7):role of the Mas receptor[J]. Behav Brain Res, 2017, 331:193-198.
[23] Seligowski AV, Duffy LA, Merker JB, Michopoulos V, Gillespie CF, Marvar PJ, Stein MB, Ressler KJ. The renin-angiotensin system in PTSD:a replication and extension[J]. Neuropsychopharmacology, 2021, 46:750-755.
[24] Nakagawa P, Sigmund CD. How is the brain renin-angiotensin system regulated[J]? Hypertension, 2017, 70:10-18.
[25] Sunanda T, Ray B, Mahalakshmi AM, Bhat A, Rashan L, Rungratanawanich W, Song BJ, Essa MM, Sakharkar MK, Chidambaram SB. Mitochondria-endoplasmic reticulum crosstalk in Parkinson's disease:the role of brain renin angiotensin system components[J]. Biomolecules, 2021, 11:1669.
[26] Gao Q, Chen R, Wu L, Huang Q, Wang XX, Tian YY, Zhang YD. Angiotensin-(1-7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson's disease[J]. Neural Regen Res, 2022, 17:1138-1145.
[27] Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons[J]. Elife, 2021, 10:e69795.

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