肠道微生物在神经系统自身免疫性疾病中的研究进展

doi:10.3969/j.issn.1672-6731.2022.01.003

摘要/Abstract

摘要： 肠道微生物是人体最直接的外环境，对维持健康具有重要作用。肠道微生物可维持人体免疫系统稳态，与宿主共生可影响人体营养、代谢和免疫功能。肠道微生物通过免疫系统和内分泌系统与神经系统产生双向联系，即微生物-肠-脑轴。肠道微生物失调引起神经系统及外周异常免疫反应，参与自身免疫性疾病的发病机制。本文综述肠道微生物在多发性硬化、视神经脊髓炎谱系疾病、自身免疫性脑炎、重症肌无力、吉兰-巴雷综合征等经典神经系统自身免疫性疾病中的研究进展。

关键词: 微生物学, 肠, 神经系统自身免疫疾病, 综述

Abstract: Gut microbiome is the most direct external environment of human body, which plays a vital role in maintaining human health. Gut microbiome maintains the homeostasis of the human immune system, which can coexist with the host and affect the nutrition, metabolism and immune function. Gut microbiome makes a mutual connection with the nervous system through the immune and endocrine systems, namely the "microbe - gut - brain" axis. Gut microbiome disorders can cause abnormal immune responses in the nervous system and the periphery, participating in the pathogenesis of autoimmune diseases. This article reviews the research progress of gut microbiome in multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSDs), autoimmune encephalitis (AE), myasthenia gravis (MG), Guillain-Barré syndrome (GBS) and other classic autoimmune diseases of the nervous system.

Key words: Microbiology, Intestines, Autoimmune diseases of the nervous system, Review

唐诗, 冯金洲, 秦新月. 肠道微生物在神经系统自身免疫性疾病中的研究进展[J]. 中国现代神经疾病杂志, 2022, 22(1): 17-22.

TANG Shi, FENG Jin-zhou, QIN Xin-yue. Research progress of gut microbiome in autoimmune diseases of nervous system[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2022, 22(1): 17-22.

https://journal11.magtechjournal.com/cjcnn/CN/Y2022/V22/I1/17

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