摘要： 偏头痛是一种临床常见的原发性头痛，严重危害人类健康和患者生活质量。近年研究表明，偏头痛患者脑白质病变发生率高于正常人群，并独立于其他脑血管病危险因素。而卵圆孔未闭在偏头痛尤其是先兆性偏头痛患者中的发生率较高，二者关系密切，但是否存在因果关系尚存争议。卵圆孔未闭可引起反常栓塞，其在偏头痛发病机制中的作用尚不十分清楚。伴或不伴卵圆孔未闭的偏头痛患者脑白质病变是否存在差异，值得研究。

关键词: 偏头痛, 脑白质病, 进行性多灶性, 卵圆孔, 未闭, 综述

Abstract: Migraine is a kind of common primary headache, which seriously damages human health and quality of life. Recent studies show there is a high incidence of white matter lesions (WML) in migraineurs, which is independent of other risk factors for cerebrovascular diseases. The patent foramen ovale (PFO) in migraineurs, especially in migraineurs with aura, is more common than in general population. There is a close relationship between them, but it is controversial whether it is a causal link. Patent foramen ovale can cause paradoxical embolism, but its role in the pathogenesis of migraine is still unknown. It is worth exploring whether there is difference in white matter lesions between the migraineurs with and without patent foramen ovale.

Key words: Migraine, Leukoencephalopathy, progressive multifocal, Foramen ovale, patent, Review